01 Hematopoiesis Flashcards Preview

02 Hematology And Immunology > 01 Hematopoiesis > Flashcards

Flashcards in 01 Hematopoiesis Deck (30):
1

Ability of stem cells to produce more stem cells

Self-renewal

2

Ability of the stem cells to differentiate into other cell types

Potency

3

The ability of a single cell to divide and produce all the differentiated cells in an organism
Only happens with a fertilized egg

Totipotency

4

Cell division gives rise to similar cell types

Symmetric division

5

Can be self renewal or potency to produce stem cell or other cell type

Asymmetric division

6

Experimental work on Unitarian theory of hematopoietic

Alexander Maximov

7

Characteristic of embryonic stem cells to form 3 germ layers

Pluritpotency

8

Mesoderm

Cardiac muscle cells
Skeletal muscle
Kidney tubules
Smooth muscle (gut)
RBC

9

Endoderm

Alveolar cell
Thyroid cell
Pancreatic cell

10

Ectoderm

Skin cells (epidermis)
Neuron cells
Pigment cells

11

Ability to become specific cell types from the three germ layers

Oligopotency

12

To develop one type of cell only

Unipotency

13

Process of differentiation of stem cells into RBC, WBC and platelets

Hematopoiesis

14

Small mauve granules
Segmented nucleus
Phagocyte foreign bodies

Neutrophils

15

Large red to purple granules with bilobed nucleus
Counteracts local allergic responses and mediate anti parasitic response

Eosinophils

16

Large blue granules
Bilobed segmented nucleus
Systemic allergic response
Can be indicative of leukemia

Basophils

17

Large round nucleus
Mediate adaptive immune response

Lymphocytes

18

Indented oval or kidney shaped nucleus
Precursor of macrophages

Monocytes

19

Can attack tumor cells and cells injured by viruses and bacteria
Uses target-oriented granules
Forms water pores on target cells for the granules to pass through

Natural Killer cells

20

APCs
Can come from both myeloid and lymphoid progenitor

Dendritic cells

21

Hormone which signals the stem cells in the bone marrow to make more RBCs
Made in kidney

Erythropoietin

22

Stages of erythropoiesis

Hemacytoblast
Proerythroblast
Early erythroblast (basophilic)
Late erythroblast (polychromathilic)
Normoblast
Reticulocyte
Erythrocyte

23

Develops into megakaryocye progenitor and erythroid progenitor

Common myeloid progenitor

24

Stages of granulopoiesis

CMP
Granulocyte and macrophage progenitor (GM-CSF)
Granulocyte progenitor
Myeloblast
Myelocyte
Metamyelocyte
Band cell

25

T cells have to differentiated in the thymus for them to not attack the body's own cells

Central tolerance

26

Kill T cells that could attack normal cells
Modify Tcell receptor so that particular T cell will not recognize self antigens

Negative selection

27

T cells that don't recognize self antigens differentiate into Helper T cells or Cytotoxic T cells

Positive selection

28

Hallmark of maturation of B cells

IgM receptor

29

Prenatal Hemaopoiesis

Yolk sac (first few weeks)
Liver (w6)
Spleen (w10)
Bone marrow (w15)

30

Post natal Hematopoiesis

Tibia and femur
Ribs, sternum, vertebrae and pelvis