Flashcards in 022014 2 Synaptic Transmission SDL Deck (33):
This type of synapse uses gap junctions, bidirectional communication, is faster, and usually excites.
This type of synapse uses neurotransmitters, unidirectional communication, is relatively slow, and can inhibit or excite.
An _____ receptor has a fast onset, short duration, and is an ion channel.
An ____ receptor has a slow onset, long duration, and uses a second messenger.
What are the receptors for acetylcholine?
What are the receptors for dopamine?
What are the receptors for noreepinephrine?
What are the receptors for epinephrine?
What are the receptors for histamine?
What is the ionotropic receptor for GABA?
What is the metabotropic receptor for GABA?
What are beta-endorphin, enkephalin, and dynorphin?
The _______ receptor is a voltage-gated dependent receptor, ligand-gated receptor, allows Ca2+ to enter neurons, and may be blocked to protect against glutamate toxicity.
How does glutamate toxicity (excitotoxicity) occur?
excess glutamate is released during CNS trauma such as stroke which leads to neuronal cell death.
Is nitric oxide a retrograde messenger that is made and released by neurons in the CNS and PNS?
How are small molecules synthesized?
enzymes are made in soma and transported to terminal, enzyme converts precursor into neurotransmitter in presynaptic cytosol, neurotransmitter packaged into vesicle
How are neuropeptides synthesized?
derived from precursors of secretory proteins, cleaved from prepropeptides into neuropeptides.
How are gases synthesized?
enzymes in postsynaptic neuron are induced to synthesize them.
Ach can't bungaroo to its receptor anymore.
blocks binding of Ach to its nicotinic receptor in PNS
Benzodiazepine (valium) MOA?
Valium chills you out.
increases frequency of GABAa Cl- channel opening
selective serotonin reuptake inhibitor (SSRI)
Pesticides kill acetylcholinesterase.
irreversibly inactivates acetylcholinesterase
Atrophied musk is musky
muscarinic receptor blocker
gaba B (baclofen)
Barbarians are chill
sedative, increases GABAa Cl- channel opening
Botulinum toxin MOA?
Botches Ach release
blocks Ach release
Cocaine helps you through mono
blocks monoamine reuptake
Curare helps Ach quit but blocking him from nicotine.
blocks Ach from binding to nicotinic receptor on skeletal muscle
Morphine feels like heroin
mimics binding of opioid peptides to produce analgesia
Awkward phenyl blocks awkward nmda
NMDA receptor blocker
Gly is a stry guy
glycine receptor blocker