022014 2 Synaptic Transmission SDL Flashcards Preview

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Flashcards in 022014 2 Synaptic Transmission SDL Deck (33):
1

This type of synapse uses gap junctions, bidirectional communication, is faster, and usually excites.

electrical

2

This type of synapse uses neurotransmitters, unidirectional communication, is relatively slow, and can inhibit or excite.

chemical

3

An _____ receptor has a fast onset, short duration, and is an ion channel.

ionotropic

4

An ____ receptor has a slow onset, long duration, and uses a second messenger.

metabotropic

5

What are the receptors for acetylcholine?

nicotinic
muscarinic

6

What are the receptors for dopamine?

D1
D2

7

What are the receptors for noreepinephrine?

alpha
beta

8

What are the receptors for epinephrine?

alpha
beta

9

What are the receptors for histamine?

H1
H2

10

What is the ionotropic receptor for GABA?

GABAa

11

What is the metabotropic receptor for GABA?

GABAb

12

What are beta-endorphin, enkephalin, and dynorphin?

opioid peptides

13

The _______ receptor is a voltage-gated dependent receptor, ligand-gated receptor, allows Ca2+ to enter neurons, and may be blocked to protect against glutamate toxicity.

NMDA

14

How does glutamate toxicity (excitotoxicity) occur?

excess glutamate is released during CNS trauma such as stroke which leads to neuronal cell death.

15

Is nitric oxide a retrograde messenger that is made and released by neurons in the CNS and PNS?

yes

16

How are small molecules synthesized?

enzymes are made in soma and transported to terminal, enzyme converts precursor into neurotransmitter in presynaptic cytosol, neurotransmitter packaged into vesicle

17

How are neuropeptides synthesized?

derived from precursors of secretory proteins, cleaved from prepropeptides into neuropeptides.

18

How are gases synthesized?

enzymes in postsynaptic neuron are induced to synthesize them.

19

Bungarotoxin MOA?

Ach can't bungaroo to its receptor anymore.

blocks binding of Ach to its nicotinic receptor in PNS

20

Benzodiazepine (valium) MOA?

Valium chills you out.

increases frequency of GABAa Cl- channel opening

21

Zoloft MOA?

Zoloft SSssss

selective serotonin reuptake inhibitor (SSRI)

22

Organophosphate MOA?

Pesticides kill acetylcholinesterase.

irreversibly inactivates acetylcholinesterase

23

Atropine MOA?

Atrophied musk is musky

muscarinic receptor blocker

24

Baclofen MOA?

gaba B (baclofen)

GABAb agonist

25

Barbiturate MOA?

Barbarians are chill

sedative, increases GABAa Cl- channel opening

26

Botulinum toxin MOA?

Botches Ach release

blocks Ach release

27

Cocaine MOA?

Cocaine helps you through mono

blocks monoamine reuptake

28

Curare MOA?

Curare helps Ach quit but blocking him from nicotine.

blocks Ach from binding to nicotinic receptor on skeletal muscle

29

Morphine MOA?

Morphine feels like heroin

mimics binding of opioid peptides to produce analgesia

30

Neostigmine MOA?

"Acetylcholinesterase!!! NNNNEEEEOOOOOOOO!!!!!!"

inhibits acetylcholinesterase

31

Phencyclidine MOA?

Awkward phenyl blocks awkward nmda

NMDA receptor blocker

32

Strychnine MOA?

Gly is a stry guy

glycine receptor blocker

33

Tricyclic antidepressants

Cocaine on a tricycle

block monoamine reuptake