Flashcards in 022614 2 Neuromuscular Diseases Deck (18):
Weakness or paralysis, spasticity, increased reflexes, babinski sign, little if any muscle atrophy. What category of neuromuscular disease?
Weakness or paralysis, flaccidity, loss of tendon reflexes, no babinski sign, muscle atrophy, fasciculations. What category of neuromuscular disease?
Numbness, impaired vibration perception, distal atrophy of hands and feet moving proximally, increases sensitivity to pain. What category of neuromuscular disease?
peripheral nerve disease
Random, multifocal weakness, severity fluctuates according to activity. What category of neuromuscular disease?
Primarily proximal weakness, muscle atrophy and decreased tendon reflexes in advanced stages. What category of neuromuscular disease?
Amyotrophic lateral sclerosis (ALS) is characterized by what?
UMN and LMN lesions
atrophy of tongue, thenar, and forearm
Spinal muscular atrophy is result of UMN or LMN lesion?
Polyneuropathy is characterized by what?
sensory and motor symptoms starting distally and moving proximally and loss of reflexes
Guillain barre syndrome is what type of polyneuropathy?
What are the three primary NMJ disorders?
lambert eaton myasthenic syndrome (LEMS)
What happens LEMS?
calcium channels prevent release of Ach
What happens botulism?
Ach release is prevented
Pupils change size
What happens in myasthenia gravis? What is also present?
anti-Ach autoantibody binds Ach receptor
muscle specific kinase antibody (MUSK)
Duchenne's muscular dystrophy, myotonic dystrophy, polymyositis, dermatomyositis, inclusion body myositis are all what category of neuromuscular disease?
Duchenne's muscular dystrophy is characterized by what?
absence of dystrophin protein
difficulty standing from all fours
muscles replaced by fat
enlarged calf muscles
increased creatine kinase
Myotonic dystrophy is characterized by what?
muscles fail to relax after contraction
dystrophia myotonica protein kinase (DMPK) mutation
Dermatomyositis is characterized by what?
red patches around eyes
darkened skin around fingers