022614 2 Neuromuscular Diseases Flashcards Preview

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Flashcards in 022614 2 Neuromuscular Diseases Deck (18):
1

Weakness or paralysis, spasticity, increased reflexes, babinski sign, little if any muscle atrophy. What category of neuromuscular disease?

UMN lesion

2

Weakness or paralysis, flaccidity, loss of tendon reflexes, no babinski sign, muscle atrophy, fasciculations. What category of neuromuscular disease?

LMN lesion

3

Numbness, impaired vibration perception, distal atrophy of hands and feet moving proximally, increases sensitivity to pain. What category of neuromuscular disease?

peripheral nerve disease

4

Random, multifocal weakness, severity fluctuates according to activity. What category of neuromuscular disease?

NMJ

5

Primarily proximal weakness, muscle atrophy and decreased tendon reflexes in advanced stages. What category of neuromuscular disease?

myopathic

6

Amyotrophic lateral sclerosis (ALS) is characterized by what?

UMN and LMN lesions
atrophy of tongue, thenar, and forearm

7

Spinal muscular atrophy is result of UMN or LMN lesion?

LMN lesion

8

Polyneuropathy is characterized by what?

sensory and motor symptoms starting distally and moving proximally and loss of reflexes

9

Guillain barre syndrome is what type of polyneuropathy?

acute

10

What are the three primary NMJ disorders?

lambert eaton myasthenic syndrome (LEMS)
botulism
myasthenia gravis

11

What happens LEMS?

calcium channels prevent release of Ach

12

What happens botulism?

Ach release is prevented
Pupils change size

13

What happens in myasthenia gravis? What is also present?

anti-Ach autoantibody binds Ach receptor
muscle specific kinase antibody (MUSK)

14

Duchenne's muscular dystrophy, myotonic dystrophy, polymyositis, dermatomyositis, inclusion body myositis are all what category of neuromuscular disease?

myopathy

15

Duchenne's muscular dystrophy is characterized by what?

DICE-MA

absence of dystrophin protein
difficulty standing from all fours
muscles replaced by fat
enlarged calf muscles
increased creatine kinase
Cardiomyopathy

16

Myotonic dystrophy is characterized by what?

muscles fail to relax after contraction
dystrophia myotonica protein kinase (DMPK) mutation
anticipation

17

Dermatomyositis is characterized by what?

red patches around eyes
darkened skin around fingers

18

What happens in inclusion body myositis?

atrophy starts in legs and leads to severely atrophied quadriceps.