03 Hemoglobin And Myoglobin Flashcards Preview

02 Hematology And Immunology > 03 Hemoglobin And Myoglobin > Flashcards

Flashcards in 03 Hemoglobin And Myoglobin Deck (27):
1

Complex of protoporphyrin IX and ferrous iron

Heme

2

Heme functions as electron carrier in ______

Cytochromes

3

Heme is part of active site of this enzyme

Catalase

4

Hb Gower 1

Embryonal hemoglobin

5

HbF

Fetal hemoglobin

6

Configuration that has low oxygen affinity

Taut form

7

Configuration that has high oxygen affinity

Relaxed form

8

Binding of oxygen in one subunit will increase the binding of oxygen for the other subunits

Positive cooperativity

9

Heme protein present in heart and skeletal muscles

Myoglobin

10

Myoglobin can be detected in plasma

Myocardial infarction

11

At high oxygen pressure

Both Hb and Mb are highly saturated

12

At low oxygen pressure

Hb has lower saturation, Mb has higher saturation

13

At very low oxygen pressure

Both Hb and Amber have low saturation

14

Factors whose interactions with one site of the Hb affects the binding of oxygen to heme groups at other locations

Allosteric effectors

15

Factors that cause shift to the right are increase in:

Carbon dioxide
Acidity
2,3 BPG
Exercise
Temperature

16

Increase in CO will cause a shift to the

Left

17

Deoxygenated Hb has a greater affinity for protons than oxyHb

Bohr effect

18

Increase in oxygen will cause carbon dioxide to unload from Hb and can b exhale to the atmosphere

Haldane effect

19

Stabilizes the T for of Hb
Low oxygen pressure will promote the synthesis
Prolonged exposure to high altitude

2,3-bisphosphoglycerate

20

Smurf syndrome, cyanotic
Oxidized form of Hb that does not bind as readily to oxygen but has increased affinity for CN
Symptoms include anxiety, headache and dyspnea

Methemoglobin

21

Inherited defect in the RBC membrane that renders the erythrocytes spheroid all, less deformable, and vulnerable to splenic sequestration and destruction
Mutations in ankyrin, spectrin, bands 4.1 and band 3
Anemia, splenomegaly, jaundice

Hereditary spherocytosis

22

Diagnosis hereditary spherocytosis

Osmotic fragility test

23

Point mutation in both genes coding for the beta chain that results in a valine rather than a glutamate
Homozygous recessive disorder
Anemia, tissue anoxia, painful crises, protective against malaria

Sickle cell disease

24

Sickle cell disease Tx

Hydration, analgesics, antibiotics, transfusions, hydroxyurea

25

Hb variant that has a single amino acid substitution in the 6th position of the beta globin chain, in which lysine is substituted for glutamate

Hemoglobin C disease

26

Inadequate production of alpha carriers
Anemia, accumulation of Hb Bart's and Hb H and beta chain ppt

Alpha thalassemia

27

Inadequate synthesis of beta chains
Anemia, accumulation of Hb Bart's and alpha chain ppt

Beta thalassemia