032515 substance abuse disorders

Question 1

substance abuse vs dependence

Answer 1

abuse-bad pattern of substance use that impairs work, physical, social functioning

dependence-abuse along with withdrawal symptoms, tolerance, or history of compulsive use

Question 2

neurochemistry of addiction

Answer 2

role of dopamine (reward)
ventral tegmental area, nucleus accumbens, prefrontal cortex

need to take it, not even b/c of withdrawal, but b/c just need to (not necessarily dependent on feeling good)

Question 3

tx for alcohol use disorder

Answer 3

disulfiram
naltrexone (opioid antagonist)
acamprosate (unknown MOA)

Question 4

tx for opiate use disorder

Answer 4

naltrexone
methadone
buprenorphine (ceiling effect-no withdrawal, no cravings)

Question 5

features of intoxication and withdrawal states in the major classes of substances

Answer 5

see BRS

Question 6

cocaine vs methamphetamine MOA

Answer 6

cocaine-inhibits dopamine reuptake transporter

methamphetamine-inhibit VMAT2 and prevent monoamines from being packaged into vesicles

Question 7

tx for substance use disorders

Answer 7

see BRS