05 Physiologic, Molecular, And Genetic Basis of the ABO Blood Type Flashcards Preview

02 Hematology And Immunology > 05 Physiologic, Molecular, And Genetic Basis of the ABO Blood Type > Flashcards

Flashcards in 05 Physiologic, Molecular, And Genetic Basis of the ABO Blood Type Deck (20):
1

Basis for ABO blood typing

Oligosaccharide antigen

2

Clumping together of mismatched blood

Agglutination

3

Occurs when the antibodies present in the recipient blood reacts with the antigens of the donor blood

ABO incompatibility

4

The serum constitutively contains antibodies to the A and B antigens that are lacking on the RBC

Landsteiner's rule

5

Newborns do not produce their own ABO antibodies until they are _______

3-6 months of age

6

Detectable ABO blood group antigens

5-6 weeks in utero

7

Pattern of inheritance of the ABO blood type

One gene-three allelic model

8

Gene involved in A and B antigen control

Chromosome 9

9

3 major alleles

A, B, O

10

A and B allele encode for ______, enzyme that catalyzes the transfer of simple sugar residues from one substance to another

Glycosyltransferase

11

Enzyme in A-allele

N-acetylgalactosaminyltransferase

12

Enzyme N-acetylgalactosaminyltransferase transfer what sugar
Immunodominant sugar for A

N-actylgalactosamine

13

Enzyme in B-allele

D-galactosyltransferase

14

Enzyme D-galactosyltransferase transfers what sugar
Immunodominant sugar for B

D-galactose

15

Considered non-functional
Rich in unconverted H antigens
Does not produce enzymatically active protein capable of acting on the H antigen precursor

O allele

16

Acceptor molecule for A and B enzymes

H antigen

17

H locus codes for _____, catalyzes the addition of terminal fucose

Fucosyltransferase

18

Genotype hh
Doesn't express H antigen but is detected as O even if they have the enzymes to create A and B antigens

Bombay phenotype

19

6 antigens of Rh blood group

C D E c d e

20

Disease of the fetus and newborn child characterized by agglutination and phagocytosis of the fetus red blood cells

Hemolytic disease of the newborn
Erythroblastic fetalis