05.06 - RBF, GFR (Rao) - PP, Lecture Guide, No reading, Not watched Flashcards Preview

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Flashcards in 05.06 - RBF, GFR (Rao) - PP, Lecture Guide, No reading, Not watched Deck (43):
1

What effect on net filtration pressure does lower urinary tract obstruction have?

Increase Pbs --> Decrease GFR

1

How does sympathetic activation affect Resistance, RPF, GFR

Constriction of Aff and Eff -> Dec RPF and Pg -> Dec GFR

1

How does Ang 2 affect renal arteriolar resistance and GFR

Induces renal arteriolar constriction and reduces GFR, paradoxically opposing auto regulation

2

How does Sympathetic affect Kf

Decrease Kf by stimulating mesangial cells -> Dec GFR

3

How does DM affect GFR

Decreases Kf, so decreases GFR

3

Higher NaCl at MD =

Inc Afferent Arteriolar R -> Dec GFR

3

Proteinuria can either be from barrier failure or ___

Abnormal Circulating Protein (breakdown of tissue, production of abnormal proteins)

4

How does dec Cl in DT affect Renin

Inc Renin -> Inc Ang II, etc

5

Net Filtration Pressure =

(Pg + Pibs) - (Pig + Pbs)

7

How does Uretral Obstruction affect GFR, FF?

Reduce GFR and thus FF

7

Kf =

Filtration Coefficient = Hydraulic Conductivity x SA of Glomerular Capillaries

7

Mechanism of GFR Autoreg: Dec GFR ->

Dec Cl in distal tubule -> MD -> Dec Arteriolar Resistance -> Inc GFR

7

When is Autoregulation more important vs Sympathetics

Autoregulation dominates under normal conditions; Sympathetics only under severe ECFV loss

8

How does Endothelin affect GFR

Constrict Arterioles (aff and eff) -> Dec GFR

9

How do sympathetics control renin

B1 receptors stimulate renin in JG cells

11

2 locations where hydrostatic pressure drops

Afferent Arteriole; Efferent Arteriole/Peritubular Capillary

14

Size of Albumin

6nm or 60 angstroms

14

How does Low Capillary Flow affect FF, Pig, Net filtration pressure, GFR

Inc FF -> Inc Pig -> Dec Net Filtration Press -> Dec GFR

14

T/F: Autoregulation in kidney depends on sympathetic input?

False, isolated in kidney

16

GFR =

Kf x Net filtration pressure

17

Lower NaCl at MD =

Dec Afferent Arteriolar R -> Inc GFR

18

Two Theories of Autoregulation

Myogenic, Tubuloglomerular Feedback

19

Adrenaline vs Endothelin 1 on resistance

Adrenaline is perferentially for Afferent, Endothelin does both

20

How does decreased efferent resistance affect GFR, RPF

Decreased GFR, Increased RPF

21

How does Adrenaline affect GFR

Constrict Arterioles (preferentially afferent) -> Dec GFR

23

Normal GFR is __ mL/min, ___ L/day

130 mL/min; 180 L/day

24

Size of glomerular pores

8nm or 80 angstroms

24

How does increased efferent resistance affect GFR, RPF?

Increase GFR, Decrease RPF

25

Hydraulic Conductivity x SA of Glomerular Capillaries

Kf (Filtration Coefficienty)

26

How does Renal Artery Stenosis affect RPF, FF?

Reduces RPF, thus increases FF

27

Anions and Cations in Glomerulus vs Ultrafiltrate

4-5% more anions in ultrafiltrate and 4-5% less cations - Gibbs Donnan effect

28

What is the filtration fraction?

GFR / RPF

30

How does decreased Afferent resistance affect GFR, RPF

Increase GFR, RPF

32

How does increase Afferent resistance affect GFR, RPF?

Decrease GFR, RPF

33

When does sympathetic response act on nephron?

Overrides autoregulation in severe ECFV loss

35

What does the Tubuloglomerular feedback mechanism sense

NaCl at Macula Densa

36

Alternate route that Inc GFR -> Inc Arterolar R

Inc GFR -> Inc Cl in DT -> Na-K-Cl in MD cells -> Release ATP or AA metabs -> SM contraction -> Inc Art R

37

How does NO affect GFR?

Decreased Vascular R -> Inc GFR

38

How does pressure affect renin release

Increased pressure in afferent arteriole inhibits renin release from JG cells; Vice versa

40

How do PG's affect GFR?

Decreased Vascular R -> Inc GFR

41

The kidneys receive what percent of cardiac output?

20%

42

Source of Endothelin that affects GFR?

Damaged endothelial cells

43

Mechanism of GFR Autoreg: Inc GFR ->

Inc Cl in distal tubule -> MD -> Inc Arteriolar Resistance -> Dec GFR