05.07 - Reg of Body Fluid (Rao) - PP, LG, No reading, Not watched Flashcards Preview

Renal > 05.07 - Reg of Body Fluid (Rao) - PP, LG, No reading, Not watched > Flashcards

Flashcards in 05.07 - Reg of Body Fluid (Rao) - PP, LG, No reading, Not watched Deck (47):
1

What percent of filtered load of Na is reabsorbed in LOF? DCT/CD?

28%, 7%

1

What increases ANP

Atrial Stretch; Plasma Pna increase

2

Renal Na excretory system responds __ to changes in Na input

Relatively slowly

3

ECFV =

(Amount of ECF Na) / Pna

3

What ion is lost in diarrhea

HCO3

3

Where are Neural Stretch Receptors

In large veins

3

Response to increases in arterial pressure on urinary Na excretion in Isolate Kidney scenario

2-3 fold increase in Na output by 30-50 mmHg change in arterial pressure

4

Effect of changes in pressure on Na excretion in Isolated Kidney vs Intact System

Takes very large increase in pressure in isolated kidney, but only a very small increase in pressure in intact system

6

Change in BW over short period indicates

Change in Na balance

7

3 Actions of ANP

(1) Dilation of Aff, Constriction of Eff - Inc GFR; (2) Inhibit Aldo secretion; (3) Inhibit Na channel phosphorylation in DT/CD

8

How do burn patients get edema

Inc Endothelial permeability -> Flux of Albumin and Fluid into ISF

8

Effect of ANP on Afferent and Efferent Arterioles

NPR1 causes dilation of Afferent, but constriction of Efferent -> Inc GFR

8

Primary Diabetes Insipidus is associated with low plasma

ADH level

9

ECFV is directly proportional to

Total Body Na content

10

How do ECF, Sympathetic, Renal Arterial BP affect Renin release

Decreased ECFV, Increased Sympathetic firing, Decreased Renal Arterial BP all increase Renin release from JG Cells

12

Pna =

(Amount of ECF Na) / ECFV

13

At constant Pna, ECFV = ____

Amount of ECF Na+

14

How long does it take to restore water balance after drinking 1 L pure water (change in plasma osmolarity)

1-2 hours

15

Timeframe of Aldosterone effect on Na reabsorption

Slow, not likely to play a role in rapid regulation of Na excretion

15

How is Aldosterone release affected by K, Angiotensin, and Na

Release stimulated by plasma K and Angiotensin; Inhibited by plasma Na

16

How do changes in GFR affect Na excretion

Increase in GFR increases Filtered Load and amount of Na excreted

17

ANP has exact opposite effect of

Aldosterone

18

3 causes of Na imbalance

Diarrhea, Excessive Sweating, Diuretics

18

Change in ECFV in response to Na intake is also

Slow

19

Receptors for ANP

NPR1/2 - Guanylate Cyclase cGMP mechanism

21

How does natriuetic hormone affect Na reabsorption

Decreases reabsorption -> Promotes excetion of Na and H20

22

3 Major "Hypovolemic Hormones"

AVP, Renin, NE

23

PV determines mean circulatory filling pressure, and therefore __

CO

24

Effect of Ouabain like factor

Diuresis and Natriuresis

25

Nephrongenic Diabetes Insipidus is associated with elevated

Plasma ADH

27

What does the difference in effect of arterial pressure on Na excretion in Isolated vs Intact systems suggest?

Pressure natriuresis is synergized with reduced formation of renin, ang 2, and aldosterone

28

How does ANP decrease Na reabsorption

In DCT via NCC; In CD via cGMP-mediated ENaC phosphorylation

30

Timeframe of balance restoration after ingestion of water vs isotonic saline

Water changes osmolarity, 1-2 hours corrected; Isotonic saline increases total Na, 2-4 days corrected

32

Is sweat isotonic?

No

34

Is vomit isotonic?

Yes

36

Change in Pna occurs only when

Gain or Loss of Na exceeds thirst mechanism and kidney's ability to correct

37

Activation of Arterial Baroreceptors -->

Pituitary --> AVP

38

Auscultation signs of edema

S3, Pulmonary Edema

39

How does Angiotensin 2 Increase Na Reabsorption

Proximal Na:H exchanger

41

Edema requires ECF increase of

2.3-3 L

41

Normal Blood Volume? Volume that causes Edema? Death?

15, 20-25, 10-12

42

Atrial Stretch Receptor Activation -->

Signal via Vagus -> Sympathetic to kidneys, ANP, decreased AVP?

43

Activation of Neural Stretch Receptors in Large Veins -->

Signals Pituitary to regulate AVP --> NK2C channels in ThickAL

44

2 Effects of NE

(1) Inc Aff and Eff arteriolar tone -> Dec GFR; (2) Inc Na, H20 reabsorption by proximal tubule

45

Direct effect of Angiotensin II

Inc Na, H2O reabsorption by proximal tubule

46

How long does it take to restore balance after 1 L of isotonic saline ingested

2-4 days

47

More severe increase in ECFV causes

Pulmonary Edema