08.21 - Cough Suppression, Decongestants, Mucolytics (Malik) - Questions Flashcards Preview

Pulmonology > 08.21 - Cough Suppression, Decongestants, Mucolytics (Malik) - Questions > Flashcards

Flashcards in 08.21 - Cough Suppression, Decongestants, Mucolytics (Malik) - Questions Deck (55):
1

Clear sputum =

Bronchitis

2

Purulent sputum =

Bronchial Infection

3

Yellow sputum =

Inflammatory Disorders

4

Maladorous Sputum =

Anaerobic Infection

5

Antitussives for non-productive coughs

Dextro, Diphenhydramine, Codeine, Camphor, Menthol

6

DOC for productive coughs with thick secretions

Guaifenesin (expectorant)

7

Antitussives with direct effect on cough center

Dextro, Diphenhydramine, Codeine

8

Action and Metabolism of Dextro

Direct inhibition of cough center; CYP2D6

9

Contraindications for Dextro

MOAi, Advanced Respiratory insufficiency, Hepatic Disease

10

Diphenhydramine is indicated for

Nonproductive cough caused by irritation (2nd line agent)

11

Action of Diphenhydramine

H1 receptor antagonist; Direct suppression of cough center - Anti-cholinergic

12

Action of Codeine

Opioid analgesic, acts on mu receptors; Direct inhibition of cough center

13

Side Effects of Codeine

Histamine Release, Vasodilation

14

Contraindications of Codeine

Pregnancy; Respiratory depression

15

Topic Anti-tussives for non-productive cough

Camphor, Menthol, Eucalyptus

16

Only FDA approved expectorant

Guaifenesin

17

Side Effects of Guaifenesin

Uric Acid Nephrolithiasis (large doses)

18

Contraindication to Guaifenesin

Hypersenstivity

19

Action of Guaifenesin

Increases volume and reduces viscosity of secretions

20

Guaifenesin is not used for

Chronic Cough

21

Congestion is due to

Dilation of blood vessels - Histamine and inflammatory mediators cause vessel dilation

22

Afferent receptor nerves are carried to

Nucleus Tractus Solitarus

23

No __ to blood vessels, no ___ to mucus glands

Para, Sympathetic

24

Phenylephrine is a selective

Alpha1-Agonist

25

Nasal Decongestants do not affect release of ___

Histamine - So commonly formulated with anti-histamines

26

2 Oral Decongestants

Pseudoephedrine, Phenylephrine

27

Pseudoephedrine acts primarily by ___, while PE acts by ___

Releasing NE, while PE directly stimulates alpha-adrenergic receptors

28

PE is metabolized by

MOA and COMT

29

Side effect profiles of Systemic Decongestants

CV Stimulation; CNS stimulation. Children and elderly more likely to experience

30

Who is more likely to experience side effects from Systemic Decongestants

Children and elderly

31

Which Decongestant causes reflex bradycardia

Phenylephrine

32

Contraindications of systemic decongestants

Bradycardia, Partial Heart Block

33

Spray Decongestants

Oxymetazoline and PE

34

Action of Oxymetazoline

Alpha1-agonist

35

Preferred topical decongestant in pregnancy

Oxymetazoline

36

Advantages of decongestant drops

Small children

37

Decongestant Inhalers

Levamfetamine and Propylhexadrine

38

Action of Levamfetamine

Stimulates NE release

39

Action of Propylhexadrine

Indirectly activates NE receptors

40

3 Expectorants

Iodinated Glycerol; Bromohexine; Guiafenesin

41

At high doses, Guiafenesin stimulates

bronchial gland secretion

42

Action of Bromohexine

Incr production of serous mucuous to decr viscosity of phlegm

43

Function of Bland Aerosols

Diliute mucus molecule

44

5 Mucolytics

N-Acetyl Cysteine; Sodium Bicarb; Dornate Alfa; Amiloride; Denufosol Tetrasodium

45

Action of N-Acetyl Cysteine

Break bonds of mucus

46

Side Effects of N-Acetyl Cysteine

Bronchospasm, Incr mucus production

47

Action of Sodium Bicarb

Incr pH of mucus

48

What is Dornase Alfa

rhDNAase

49

Action of Dornase Alfa

Reduce viscosity of secretions by breakin gdown extracellular DNA

50

Indications fo Dornase Alfa

CF, CB, Bronchiectasis

51

Contraindications of Dornase Alfa

Chinese Hamster Ovary Cell products

52

Side effects of Dornase Alfa

Voice alteration, Chest pain

53

Action of Amiloride

Diuretic (Na channel blocker) given to CF patients to prevent dehydration of mucus

54

Diuretic (Na channel blocker) given to CF patients to prevent dehydration of mucus

Amiloride

55

Action of Denufosol Tetrasodium

Activates Cl secretion and inhibits Na transport (P2Y2 receptor activation) --> Mucosal hhydration and clearance