1) Cholinomimetics Flashcards Preview

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Flashcards in 1) Cholinomimetics Deck (51)
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1

What is the class for Bethanechol (Urecholine)

Direct acting carbamic acid ester

2

What is the mechanism for Bethanechol (Urecholine)

Direct-acting muscarinic cholinomimetic

3

What are the therapeutics for Bethanechol (Urecholine)

Post-operative and neurogenic ileus; urinary retention (bowel and bladder smooth muscle ACh-innervated)

4

What are the important side effects for Bethanechol (Urecholine)

SLUDGE

5

What is the class for Muscarine

Direct acting non-ester alkaloid

6

What is the mechanism for Muscarine

Direct-acting muscarinic cholinomimetic

7

What are the important side effects for Muscarine

SLUDGE

8

What is the class for Pilocarpine (Salagen)

Direct acting non-ester alkaloid

9

What is the mechanism for Pilocarpine (Salagen)

Direct-acting muscarinic cholinomimetic

10

What are the therapeutics for Pilocarpine (Salagen)

Glaucoma (ACh activates sphincter and ciliary muscles of eye)

11

What are the important side effects for Pilocarpine (Salagen)

SLUDGE

12

What is the class for Cevimeline (Evoxac)

Direct acting non-ester alkaloid

13

What is the mechanism for Cevimeline (Evoxac)

Direct-acting muscarinic cholinomimetic

14

What are the therapeutics for Cevimeline (Evoxac)

Dry mouth (in, e.g., Sjogren's, post-radiation therapy; via increased salivation)

15

What are the important side effects for Cevimeline (Evoxac)

SLUDGE

16

What is the class for Nicotine (NRT)

Direct acting non-ester alkaloid

17

What is the mechanism for Nicotine (NRT)

Direct-acting nicotinic cholinomimetic

18

What are the therapeutics for Nicotine (NRT)

Smoking cessation (reduces cravings)

19

What is the class for Neostigmine (Prostigmin)

Indirect acting carbamate

20

What is the mechanism for Neostigmine (Prostigmin)

AChE inhibitor (short acting)

21

What are the therapeutics for Neostigmine (Prostigmin)

Post-operative and neurogenic ileus; urinary retention; myasthenia gravis; reversal of neuromuscular blockade

22

What are the important side effects for Neostigmine (Prostigmin)

SLUDGE + general increase in cholinergic neurotransmission; paralysis

23

What are the miscellaneous for Neostigmine (Prostigmin)

Lasts 0.5-2 hours

24

What is the class for Physostigmine (Eserine)

Indirect acting carbamate

25

What is the mechanism for Physostigmine (Eserine)

AChE inhibitor (short acting)

26

What are the therapeutics for Physostigmine (Eserine)

Glaucoma (ACh activates papillary sphincter and ciliary muscles of eye)

27

What are the important side effects for Physostigmine (Eserine)

SLUDGE + general increase in cholinergic neurotransmission; paralysis

28

What are the miscellaneous for Physostigmine (Eserine)

Lasts 0.5-2 hours

29

What is the class for Donepezil (Aricept)

Indirect acting non-ester

30

What is the mechanism for Donepezil (Aricept)

AChE inhibitor