1. Kidney embryology Flashcards Preview

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Flashcards in 1. Kidney embryology Deck (32):
1

intermediate mesoderm gives rise to

urogenital ridge

2

Urogenital ridge gives rise to ... (and then )

nephrogenic ridge --> develops into 3 steps of nephric structure ---> a. pronephros b . mesonephros c. metanephros

3

sets of nephric structure ( and area)

1. pronephros ( upper - cranial most)
2. mesoneprhros ( middle)
3. metanephros ( lower -caudal most)

4

pronephros - time

apperas at week 4 and then degenerates

5

pronephros - function

not functional in humans 5

6

pronephros develops by

the differentiation of mesoderm within the nephrogenic cord to form pronephric tubules and the pronephric duct

7

mesonephros develops by

the differentiation of mesoderm within the nephrogenic cord to form mesonephric tubules and the mesonephric duct (wolffian duct)

8

mesonephric duct is AKA

Wolffian duct

9

mesonephros function

1. interim kidney for 1st trimester
2. later contributes to male genital center ( mesonephric duct)

10

mesonephros - regression

most of mesonephric tubules regress, but the mesonephric duct ( Wolffian duct ) persists to open into urogenital sinus

11

Metanephros time

1st appears in5th week of gestation --> nephrogenesis continuous through 32-36 weeks of gestation

12

metanephros is functional in fetus in (time)

week ten

13

metanephros is consist by

1. ureteric bud
2. metanephric parenchyma ( metanephric blastema)

14

metanephros is consist by ... ( developed by)

1. ureteric bud --> derived from caudal end of mesonephric duct
2. metanephric parenchyma ( metanephric blastema)--. condensation of mesoderm within nephrogenic cord

15

metanephros is consist by (gives rises generally )

1. ureteric bud --. collecting system
2. metanephric parenchyma ( metanephric blastema)---> nephron

16

ureteric bud gives rise to ( explain )

collecting system : it penetrates metanephric mesoderm to form the ureter, pelvises , calyces, collectind ducts

17

ureteic bud is fully canalized at

10th week

18

aberant interaction between ureteric bud and metanephric mesoderm may result

several congenital malformations of kidney

19

renal - DCT

distal concoulate tubule

20

MC of renal system obstruction ( hydronephrosis ) in fetus (and why)

ureteropelvic junction - last to canalize

21

kidney embryology - last to canalize

ureteropelvic junction

22

• The kidneys of a 4-week-old human embryo are examined. The development of which structure is expected to be seen?

The pronephros

23

• After week 4, what happens to the pronephros?

The pronephros degenerates

24

During which trimester of fetal development does a structure that eventually contributes to the male genital system arise?

During the first trimester, the mesonephros, which later contributes to male genital system, begins to develop

25

• What fetal structure functions as the interim kidney for the first trimester?

Mesonephros

26

• A researcher wishes to physically block development of the ureteric bud. Where must he stall development?

The caudal end of the mesonephros

27

What adult structures in the urinary tract are derived from the ureteric bud?

• Collecting ducts, calyces, pelvises, and ureters

28

• What adult structures in the urinary tract are derived from the metanephric mesenchyme?

Structures in the kidney, from the glomerulus to the distal convoluted tubule

29

• What is the most common cause of hydronephrosis in a fetus? Why?

Ureteropelvic junction obstruction; the ureteropelvic junction is the last structure to canalize

30

• The interaction of which two structures/tissues in the developing kidney induces proper differentiation and formation of the renal tubules?

Ureteric bud and metanephric mesenchyme (aberrant interaction leads to congenital malformations)

31

• The ____ (pronephros/mesonephros/metanephros) appears at week 5 of gestation and is permanent.


Metanephros

32

• After formation of the ____, nephrogenesis continues through weeks 32–36 of gestation.


Metanephros

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