10 & 11 Pharm: Management of Anemias and Cytopenias + Hemostasis and Coagulation

Question 1

Iron Deficiency Anemia Treatment

• What 3 things can you give?
• What do you tell patients not to have?
• What issues arise from increased Iron intake?

Answer 1

Question 2

Treatment of Vitamin B12 Deficiency Anemia

• What do you give?
• What ADRs exist?

Answer 2

Question 3

Treatment of Folic Acid Deficiency Anemia

• What do you give for replacement?
• What do you give for malabsorption?

Answer 3

Question 4

Erythropoietin stimulating agents (ESAs)

• What are the 2 agents?
• What are the 2 major ADRS?
  
  • What do you need to monitor?

Answer 4

Question 5

Sickle Cell Anemia: Drugs that stimulating HbF expression in adults

Answer 5

Question 6

5-Azacytidine & Decitabine

• How do these treat sickle cell?
• What ADRs exist?

Answer 6

Question 7

Hydroxyurea

• How does this treat sickle cell?
• What ADRs exist?

Answer 7

Question 8

Treatment of Neutropenia

• What are the 3 drugs?
  
  • What drug is associated with G-CSF?
    
    • What drug the same as the answer to the above question, with a longer half-life??
  • What drug is associated with GM-CSF?
    
    • What unique ADRs does this drug have?
• What is the common ADR for all these drugs?

Answer 8

Question 9

Treatment of Thrombocytopenia

• What are the 3 drugs for this?
  
  • What drug is associated with IL-11 and chemotherapy?
    
    • What ADRs does the above drug have?
  • What drug is a Thrombopoietin receptor agonist?
  • What drug is a Recombinant IgG1 Fc-peptide protein?
  • What drugs have the exact same ADRs, and what are the ADRS?

Answer 9

Question 10

Coagulation Factor Groups

• Vitamin K-dependent Factors (4)
• Contact Activation Factors (4)
• Thrombin-sensitive Factors (4)

Answer 10

Question 11

• What is the hemophilia associated with males and factor 8?
• What is the hemophilia associated with factor 9?

Answer 11

Question 12

What is used to treat Hemophilia A?

Answer 12

Question 13

Factor Products Adverse Side Effects (5)

Answer 13

Question 14

How should immunizations for Hemophilia patients be approached?

Answer 14

Question 15

• What is the Most serious complication of factor replacement therapy?
  
  • What are the 2 patient groups for the answer to the above question?

Answer 15

Question 16

Clinical Manifestation of von Willebrand Disease

• What does VWF bind to?
• What does it do?
• How do patients present?

Answer 16

Question 17

What is used to treat von Willebrand Disease?

What are the ADRs?

Answer 17

Question 18

What is Immune Thrombocytopenic Purpura (ITP)?

Answer 18

Question 19

• What is used to treat these forms of Immune Thrombocytopenic Purpura (ITP)?
  
  • Rh (+) patients
  • Rh (-) patients
  • Refractory ITP if the above drugs don’t work

Answer 19