10. Appetite regulation Flashcards Preview

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Flashcards in 10. Appetite regulation Deck (20):
1

Appetite regulation - hormones

1. Ghrelin
2. Leptin
3. Endocannabinoids

2

satiety hormone

Leptin

3

Hungry hormone

Ghrelin

4

Ghrelin function

1. stimulates hunger ( orexigenic effect)
2. GH release ( via GH secretagig receptro)

5

Ghrelin is produced by

stomach

6

Ghrelin is increased in ( situations )

1. sleep loss
2. Prader-Willi syndrome

7

Leptin produced by

adipose tissue

8

Mutation of leptin gene -->

congenital obesity

9

Leptin produced by

adipose tissue

10

Leptin is decreased during

1. starvation
2. sleep deprivation

11

appetite regulation - endocannabinoids mechanisms of action

act at cannbinoid receptros in hypothalamus and nucleus accumbens ( 2 key rain areas for homeostatic and hedonic control of food intake) --> increased appetite ( THE MYNCHIES)

12

appetite regulation - sleep deprivation

1. decreased leptin
2. increased Ghrelin

13

2 key brain areas for homeostatic and hedonic control of food intake

1. hypothalamus
2. nucleus accumbens

14

apettite regulation - endocannabinoids act at

canabinoid receptros in hypothalamus and nucleus accumbens ( 2 key rain areas for homeostatic and hedonic control of food intake

15

Why would a patient complain of an increased appetite when they have had a reduction in sleep?

Increased ghrelin level with sleep loss (ghrelin has an orexigenic effect, stimulating hunger [ghrelin makes you hunghre])

16

A patient states that she no longer has the ability to feel satiated after meals. Dysfunction of what hormone could account for this?

Leptin, produced by adipose tissue (leptin keeps you thin)

17

• What class of hormones, also present in medical marijuana, stimulate hunger?

Endocannabinoids stimulate cortical reward centers, increasing desire for high-fat foods (the munchies)

18

• Patients with Prader-Willi syndrome are known to be overweight. Increased production of which hormone accounts for their increased appetite?

Ghrelin (ghrelin makes you hunghre)

19

• A biochemist, wishing to test you, asks, "What is the mechanism of action of the key signaling molecule with an orexigenic effect?"

Ghrelin stimulates hunger (orexigenic effect—ghrelin makes you hunghre) and GH release via a GH secretagog receptor

20

• Patients w/ Prader-Willi syndrome are overweight, with significantly increased appetites. An excess of which signaling molecule is to blame?

Overproduction of ghrelin, which promotes growth horone release (via a secretagog receptor) stimulates hunger.