Flashcards in 10. Appetite regulation Deck (20):
Appetite regulation - hormones
1. stimulates hunger ( orexigenic effect)
2. GH release ( via GH secretagig receptro)
Ghrelin is produced by
Ghrelin is increased in ( situations )
1. sleep loss
2. Prader-Willi syndrome
Leptin produced by
Mutation of leptin gene -->
Leptin produced by
Leptin is decreased during
2. sleep deprivation
appetite regulation - endocannabinoids mechanisms of action
act at cannbinoid receptros in hypothalamus and nucleus accumbens ( 2 key rain areas for homeostatic and hedonic control of food intake) --> increased appetite ( THE MYNCHIES)
appetite regulation - sleep deprivation
1. decreased leptin
2. increased Ghrelin
2 key brain areas for homeostatic and hedonic control of food intake
2. nucleus accumbens
apettite regulation - endocannabinoids act at
canabinoid receptros in hypothalamus and nucleus accumbens ( 2 key rain areas for homeostatic and hedonic control of food intake
Why would a patient complain of an increased appetite when they have had a reduction in sleep?
Increased ghrelin level with sleep loss (ghrelin has an orexigenic effect, stimulating hunger [ghrelin makes you hunghre])
A patient states that she no longer has the ability to feel satiated after meals. Dysfunction of what hormone could account for this?
Leptin, produced by adipose tissue (leptin keeps you thin)
• What class of hormones, also present in medical marijuana, stimulate hunger?
Endocannabinoids stimulate cortical reward centers, increasing desire for high-fat foods (the munchies)
• Patients with Prader-Willi syndrome are known to be overweight. Increased production of which hormone accounts for their increased appetite?
Ghrelin (ghrelin makes you hunghre)
• A biochemist, wishing to test you, asks, "What is the mechanism of action of the key signaling molecule with an orexigenic effect?"
Ghrelin stimulates hunger (orexigenic effect—ghrelin makes you hunghre) and GH release via a GH secretagog receptor