Flashcards in 10. Differentiation of T cells Deck (16):
Differentiation of T- cells ( and location )
T- cell precursor ( no CD4 , 8, TCell receptor ) in bone marrow --> T cell with CD4, cD8 ( both and T-cell receptor ( cortex of thymus) --> T- cells with TCR an either CD8 or CD4 (medulla of Thymus) -->
CD8Q Cytotxic T cells ( lymph node)
CD4 Q Helper T cells (lymph node
TGF-β + IL-6 : Th14
Central tolenance is the
mechanism by which newly developing T cells and B cells are rendered non reactive to self
Central tolerance is the
mechanism by which newly developing T cells and B cells are rendered non - reactive to self
Central tolerance - T cells - type ( and location)
1 positive selection ---> thimic cortex
2. Negative selection --> thimic medulla
T cells positive selection - location and mechanism
LocationQ thymic cortex
T cells expressing TCRs capable of binding surface self -MHC molecules survive
T cells negative selection - location and mechanism
location : thymic medulla
T cells expressing TCRs with high affinity for seld antigens undergo apoptosis --> Tissue restricted self antigens are expressed in thymus due to the action of autoimmune regulator (AIRE)
AIRE --> transcription factor --> major proteins from elsewhere in the body (tissue - restricted antigens)
Autoimmune regulator ( AIRE ) mutation
Autoimmune poly endocrine syndrome - 1
• Describe the process of positive and negative selection of T cells.
Positive selection identifies T cells that recognize MHC, whereas in negative selection, T cells reactive to self antigens apoptosis
Th1, Th2, and Th17 cells are specialized descendants of which type of cell?
CD4+ helper T cells
Which cytokines induce differentiation of helper T cells to Th1, Th2, and Th17 cells, respectively?
IL-12, IL-4,TGF-β plus IL-6
Interleukin12 induces helper T cells to differentiate to____(Th1/Th2) cells as part of____(cellular/humoral) immunity.
Immature T cells go from bone marrow to the thymic cortex for ____ (positive/negative) selection, becoming ____ (CD4/CD8/CD4+CD8) T cells.
Positive, CD4 plus CD8
CD4+ T cells give rise to ____ (helper T/cytotoxic T/NK) cells. CD8+ T cells give rise to ____ (helper T/cytotoxic T/NK) cells.
Helper T, cytotoxic T
Interleukin 4 induces helper T-cell differentiation to ____(Th1/Th2) cells as part of ____(cellular/humoral) immunity.
Th2 cells, humoral
What are three kinds of cells that cytotoxic T cells kill?
Virus-infected, neoplastic, and donor graft cells