10. Heme/Onc Flashcards

1
Q

t(9;22) translocation

associated disorder?

A

(Philadelphia chromosome)

bcr-abl hybrid -> Chronic myelogenous leukemia (CML)

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2
Q

t(8;14) translocation

what disorder?

A

Burkitt lymphoma (c-myc activation)

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3
Q

t(11;14) translocation

what disorder?

A

Mantle cell lymphoma (cyclin D1 activation)

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4
Q

t(14;18)

what disorder?

A

Follicular lymphomas (bcl-2 activation)

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5
Q

t(15;17)

what disorder?

A

M3 type of AML

(responds to all-trans retinoic acid - ATRA)

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