10 minute topic Lupus Flashcards Preview

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Flashcards in 10 minute topic Lupus Deck (20):
1

Systemic Lupus Erythematosus

Autoimmune
chronic inflammation and destruction of tissue
no cure
exacerbations and remissions

2

SLE triggers

toxins
medications
bacteria
viruses

3

Discord SLE

primarily affects the skin
characterized by an erythematosus butterfly rash over the nose and cheeks and is generally self-limiting

4

Systemic SLE

affects the connective tissues of multiple organ systems and can lead to major organ failure

5

SLE risk factors

women 15-40
African american, asian or native american

6

SLE s/sx

fatigue
alopecia
anorexia
fever (in exacerbation)
joint pain/swelling
anemia
Raynaud's phenomenon
lymphadenopathy

7

Raynaud's phenomenon

arterial vasospasm in the hands or feet, typically in response to cold or stress

8

Antinuclear antibody (ANA) titer

there is a positive ANA titer in 90% of clients who have lupus

9

Anti-DNA test

positive in SLE but not specific for SLE dx

10

Extractable nuclear antibodies (ENAs)

positive with SLE

11

Serum complement (C3, C4)

decreased in SLE
diagnostic for SLE because they decrease due to depletion secondary to an exaggerated inflammatory response

12

BUN and creatinine

increased with kidney involvement with SLE

13

Urinalysis

will be positive for protein and RBC's

14

CBC

may show pancytopenia with SLE

15

Medications for SLE

NSAIDS
Corticosteroids
Immunosuppressants
Antimalarial

16

Immunosuppresants ex

Methotrexate and azathioprine (Imuran)
Monitor for toxic effects (bone marrow suppression, increased liver enzymes)

17

Antimalarial ex

hydroxychloroquine (Plaquenil)
used for suppression of synovitis, fever, and fatigue
Encourage frequent eye examinations

18

Education for SLE PT's

Avoid sun exposure, use sunscreen
Use steroid creams for rash
Avoid crowds and infection

19

Lupus nephritis

SLE complication
renal failure
may be caused by corticosteroid use

20

Pericarditis/myocarditis

SLE complication
inflammation of the heart/surrounding sac