10.30 Serotonin Flashcards
(26 cards)
enterochromaffin cell (release 5HT) tumor will have increased
5HIAA
terminating action of 5HT dependent on
reuptake
only 5HT receptor that’s not G protein coupled
5HT3
receptor for migraines
5HT1D/1B
receptor at vomiting center
5HT3
receptor in enteric nervous system that releases ACh for pro kinetic response
5HT4
receptor on GI smooth muscle
5HT2
receptor for platelet aggregation
5HT2
receptor for serotonin syndrome
5HT2
lorcaserin targets what receptor
5HT2C
drug for weight loss
lorcaserin
precautions for lorcaserin
serotonin syndrome
heart failure
hypoglycemia
emergency use for chronic constipation or IBS with constipation
tegaserod
investigational use for GERD
cisapride
5HT3 antagonists for nausea and vomiting
ondansetron
dolasetron
granisetron
palonosetron
5HT3 antagonists for diarrhea dominant IBS
alosetron
best for delayed chemo induced N/V b/c long half life
palonosetron (5HT3 antagonist)
prodrug
dolasetron (5HT3 antagonist)
for morning sickness, alcoholism, pruritus from cholestasis
ondansetron (5HT3 antagonist)
prolong QT interval
dolasetron (5HT3 antagonist)
can cause skin rash
granisetron (5HT3 antagonist)
histamine and serotonin antagonist
cyproheptadine
cyproheptadine used for
allergies, tx serotonin syndrome, tx carcinoid tumors
tx of serotonin syndrome if BP too high
esmolol
nitroprusside
