11. Antidiuretic hormone Flashcards Preview

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Flashcards in 11. Antidiuretic hormone Deck (17)

ADH ( vasopressin ) - synthesized in / released by

supraoptic nuclei ( hypothalamus)
posterior pituitary ( neurohypophysis


ADH ( vasopressin ) function (via(

1. regulates serum osmolarity (v2)
2. regulates blood pressure (v1)


ADH ( vasopressin) regulates serum osmolarity ( mechanisms )

via V2 receptor
decreases serum osmolarity ( and increases urine osm) via regulation of aquaporin channel insertion in principle cells of renal collecting ducts


ADH ( vasopressin) effect on serum and urine osmolarity

decrease serum
increased urine


ADH regulates blood pressure via

constriction of vascular smooth muscle via Vi receptor


ADH levels in CDII and nephrogenic DI

increased in Nephrogenic and decreased in central


nephrogenic diabetes insipidus can be caused by

mutation of V-2 receptros


treatment of central diabetes insipidus

ADH analog ( Desmopressin acetate)


Desmopressin acetate is the treatment for

CDI and nocturnal enuresis


ADH ( vasopressin ) regulation

1. osmoreceptors in hypothalamus ( 1ry)
2. hypovolemia (2ry)
3. icreased by AT II


ADH vs oxytocin according to production area in hypothalamus

ADH ---> supraoptic nuclei
oxytocin --> paraventricular nuclei


A patient has transient loss of blood to his posterior pituitary. His blood is found to be hypernatremic. Why?

Hypothalamus—posterior pituitary damage causes a reduction in ADH secretion, thus causing increased diuresis (central diabetes insipidus)


What receptors are involved in ADH's function?

V1-receptors regulate BP, V2-receptors regulate serum osmolarity, and ADH's main function is serum osmolarity regulation


What is the site of action of ADH in the kidney?

Principal cells of the renal collecting duct


A thirsty man with normal serum osmolarity has elevated ADH levels. Why might this be the case?

A secondary function of ADH is to promote volume retention in hypovolemia


A boy is found to have high serum sodium levels. He has never taken lithium. Renal biopsy shows a receptor mutation. What is happening?

He likely has a V2-receptor mutation, leading to nephrogenic diabetes insipidus


A patient has SIADH as a result of lung cancer. What changes would you expect in his serum and urine osmolarity?

Decrease in serum osmolarity, increase in urine osmolarity (urine more concentrated because free water is reabsorbed back into blood)