Flashcards in 11. Antidiuretic hormone Deck (17)
ADH ( vasopressin ) - synthesized in / released by
supraoptic nuclei ( hypothalamus)
posterior pituitary ( neurohypophysis
ADH ( vasopressin ) function (via(
1. regulates serum osmolarity (v2)
2. regulates blood pressure (v1)
ADH ( vasopressin) regulates serum osmolarity ( mechanisms )
via V2 receptor
decreases serum osmolarity ( and increases urine osm) via regulation of aquaporin channel insertion in principle cells of renal collecting ducts
ADH ( vasopressin) effect on serum and urine osmolarity
ADH regulates blood pressure via
constriction of vascular smooth muscle via Vi receptor
ADH levels in CDII and nephrogenic DI
increased in Nephrogenic and decreased in central
nephrogenic diabetes insipidus can be caused by
mutation of V-2 receptros
treatment of central diabetes insipidus
ADH analog ( Desmopressin acetate)
Desmopressin acetate is the treatment for
CDI and nocturnal enuresis
ADH ( vasopressin ) regulation
1. osmoreceptors in hypothalamus ( 1ry)
2. hypovolemia (2ry)
3. icreased by AT II
ADH vs oxytocin according to production area in hypothalamus
ADH ---> supraoptic nuclei
oxytocin --> paraventricular nuclei
A patient has transient loss of blood to his posterior pituitary. His blood is found to be hypernatremic. Why?
Hypothalamus—posterior pituitary damage causes a reduction in ADH secretion, thus causing increased diuresis (central diabetes insipidus)
What receptors are involved in ADH's function?
V1-receptors regulate BP, V2-receptors regulate serum osmolarity, and ADH's main function is serum osmolarity regulation
What is the site of action of ADH in the kidney?
Principal cells of the renal collecting duct
A thirsty man with normal serum osmolarity has elevated ADH levels. Why might this be the case?
A secondary function of ADH is to promote volume retention in hypovolemia
A boy is found to have high serum sodium levels. He has never taken lithium. Renal biopsy shows a receptor mutation. What is happening?
He likely has a V2-receptor mutation, leading to nephrogenic diabetes insipidus