Flashcards in 11. Helper T cells Deck (13):
Helper T cells - tyoe
Th1 vs Th2 according to secretions
Th1 secretes IFN- γ
Th2 secretes IL-4, IL-5. IL-10, IL-13
Th1 vs Th2 according to function
Th1 activates macrophages and cytotoxic cells R cells
Th2 recruits eosinophils for parasite defense and promotes Ig E production by B cells
Th1 vs Th2 according to activation
Th1 activated by ΙΝΦ- γ+ IL 12
Th2 activated by: IL-4
Th1 vs Th2 according to inhibition
Th1 inhibited by IL4 + IL 10 (th1)
Th2 activated by: IINF-γ (from Th2)
T cell differentiation to Th1 - mechanism
Macrophage- ;ymphocyte interaction - macrophage release IL-12, which stimulates T-cells to differentiate into TH1 cells . Th1 cells release IFN γ to stimulate macrophages
• Th1 cells regulate ____ (cellular/humoral) immunity; Th2 cells regulate ____ (cellular/humoral) immunity.
Th1 cells secrete cytokine ____ and are inhibited by cytokines ____. They activate two cell types; these are ____ and ____.
Interferon-γ,interleukin 4 and interleukin 10 (from Th2); macrophages; CD8+ cells (cytotoxic T lymphocytes)
Th2 cells secrete cytokines ____, ____, ____, #38; ____ to stimulate Ig class switching in B cells. They are inhibited by cytokine ____.
Interleukin (IL) 4, IL-5, IL-6, IL-13; interferon-γ (from Th1 cells)
Th1 cells secrete ____ to activate macrophages; macrophages secrete ____ to stimulate T cell differentiation to Th1
Th1 cells secrete ____, inhibiting Th2 cells. Th2 cells secrete ___ and ___, inhibiting Th1 cells.
Interferon-γ IL-4; IL-10
Helper T cells possess ____, which binds to ___ on ____ cells.
CD4; MHC II, antigen-presenting