11. Helper T cells Flashcards Preview

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Flashcards in 11. Helper T cells Deck (13):
1

Helper T cells - tyoe

Th1
Th2
Th17

2

Th1 vs Th2 according to secretions

Th1 secretes IFN- γ
Th2 secretes IL-4, IL-5. IL-10, IL-13

3

Th1 vs Th2 according to function

Th1 activates macrophages and cytotoxic cells R cells
Th2 recruits eosinophils for parasite defense and promotes Ig E production by B cells

4

Th1 vs Th2 according to activation

Th1 activated by ΙΝΦ- γ+ IL 12
Th2 activated by: IL-4

5

Th1 vs Th2 according to inhibition

Th1 inhibited by IL4 + IL 10 (th1)
Th2 activated by: IINF-γ (from Th2)

6

T cell differentiation to Th1 - mechanism

Macrophage- ;ymphocyte interaction - macrophage release IL-12, which stimulates T-cells to differentiate into TH1 cells . Th1 cells release IFN γ to stimulate macrophages

7

• Th1 cells regulate ____ (cellular/humoral) immunity; Th2 cells regulate ____ (cellular/humoral) immunity.

Cellular; humoral

8

Th1 cells secrete cytokine ____ and are inhibited by cytokines ____. They activate two cell types; these are ____ and ____.

Interferon-γ,interleukin 4 and interleukin 10 (from Th2); macrophages; CD8+ cells (cytotoxic T lymphocytes)

9

Th2 cells secrete cytokines ____, ____, ____, #38; ____ to stimulate Ig class switching in B cells. They are inhibited by cytokine ____.

Interleukin (IL) 4, IL-5, IL-6, IL-13; interferon-γ (from Th1 cells)

10

Th1 cells secrete ____ to activate macrophages; macrophages secrete ____ to stimulate T cell differentiation to Th1

Interferon-γ; interleukin-12

11

Th1 cells secrete ____, inhibiting Th2 cells. Th2 cells secrete ___ and ___, inhibiting Th1 cells.

Interferon-γ IL-4; IL-10

12

Helper T cells possess ____, which binds to ___ on ____ cells.

CD4; MHC II, antigen-presenting

13

A patient has a parasitic infection. An experimental recombinant form of interleukin 4 is administered. Will this benefit the patient?


In theory, yes, as interleukin 4 stimulates Th2 cells, which in turn recruit eosinophils for parasite defense