Flashcards in 11.2 - Dementia Deck (10)
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1
Define dementia
progressive decline of cognitive function (impairment of intellect, reason and personality without impairment of consciousness), usually affecting the cortex as a whole (though can sometimes be patchy)
2
What are the most common causes of dementia?
AD, dementia with lewy bodies, vascular dementia
3
Describe the symptoms of AD
progressive memory loss, aphasia, apraxia, agnosia, depression, behavioural changes
4
What is pathophysiology of AD?
Neurofibrillary tangles - Twisted filaments of tau protein. Tau stabilises microtubules in cell.
Senile plaques - amyloid deposition of aBeta protein.
5
Symptoms of lewy body dementia?
Fluctuating cognition. More rapid symptoms than AD.
6
What causes vascular dementia
multiple infarcs in cortex.
7
What is frontotemporal dementia?
Atrophy of frontal and temporal lobes
8
What are subcortical encephalopathies
Disorders that affect subcortical structures e.g. huntingtons disease and parkinsons
9
What are primary progressive aphasia?
language based dementia
10
