12 Antigen Processing and Presentation Flashcards Preview

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Flashcards in 12 Antigen Processing and Presentation Deck (15):
1

Immune system's reaction to antigens

Immune response

2

Immune response phases

Initiation phase
Effector phase

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When APC will present the peptides bound to MHC to naive lymphocyte

Initiation phase

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When activated T cells will try to get rid of the infection

Effector phase

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Display of peptide fragments on the MHC to T cells

Antigen presentation

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Conversion of native proteins to MHC-associated peptide fragments by APCs

Ag processing

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Substances that can mobilize immune system
Usually foreign substance

Antigens

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Capable of stimulating activation process leading to proliferation of specific lymphocytes and antibody production

Complete antigens

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Incomplete antigens
Incapable of stimulating immune response

Haptens

10

Antigenic determinant groups
Specific regions on an antigen recognized by specific antigen presenters

Epitopes

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Captures antigens, transports them to peripheral lymphoid tissues, and presents them to lymphocytes
Convert and display

Antigen presenting cell

12

Normally in immature state
Become mature en route to lymph node
Most effective APC for T cells because of optimal location, receptors, preferential migration, expresses co-stimulators

Dendritic cell

13

Mediated by macrophages and effector cells
Central reaction in CMI, delayed type hypersensitivity

Cell-mediated immune response

14

Tags the foreign substances in the cytosol

Ubiquitin

15

Acts as peptide exchanger
Facilitates Class-II associated invariant chain peptide removal

Human leukocyte antigen-DM