1.2 Receptor Physiology and Cell Signaling Flashcards Preview

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Flashcards in 1.2 Receptor Physiology and Cell Signaling Deck (19):
1

Acts as transducers in the signaling pathway.

Receptor

2

translation of external signal into intracellular events that will produce the response to that signal

Signal transduction

3

Also the first messengers

Ligands

4

Type of receptors which bind to lipophilic or lipid soluble ligands

Intracellular receptors

5

Type of receptor with slower onset of effect

Intracellular receptors

6

Type of receptor with faster onset of effects

Cell membrane receptors

7

Type of receptors which alter gene expression

Intracellular receptors

8

Type of receptors that make use of 2nd messengers and usually activate KINASES to phosphorylate proteins.

Cell membrane receptors

9

Is bound to the inactive cytoplasmic receptor to keep the receptor in the cytoplasm; a chaperone protein

Heat Shock Protein

10

Second messenger of effector Adenylyl Cyclase

cAMP

11

second messengers of PLC (as effector)

DAG and IP3

12

Pathway of adenylyl cyclase as effector

activated adenylyl cyclase converts ATP to cAMPcAMP activates PKAPKA liberates catalytic subnutis to phosphorylate target proteins--> CREB-->gene expression

13

Pathway of PLC as effector

activated PLC hydrolizes PIP2 into DAG and IP3DAG remains in the cell membraneIP3 bind to IP3 gated calcium channels in ER which opens the calcium channelsCalcium ions are released into cytosolDepletion iif intracellular calcium will activate SOC channelsIncrease in intracellular calcium and DAG will activate PKC which phosphorylates multiple targets

14

Second messenger of PLA2

eicosanoids

15

Second messengers of cyclooxygenase

prostaglandins, prostacyclins, thromboxanes

16

Receptor of ANP

Guanylyl cyclase

17

Receptor of TGF-B; involved in phosphorylation of SMAD

Serine/Threonine Kinases

18

Receptor of Nerve Growth Factor (NGF; MAPK pathway) and Insulin (PI3K pathway); JAK

Tyrosine Kinases

19

Enzymes which phosphorylates protein substrates

Enzyme