Flashcards in 13. Filtration Deck (15):
renal filtration fraction - definition
is the ratio of the glomerular filtration rate ( GFR) to the renal plasma flow ( RPF)
Renal filtration fraction - calculation and normal value
FF = GFR / RPF = 20% ( normally)
filtered load calcularion
filtered load ( mg /min) = GFR ( ml/min ) x plasma concentration
• How is the filtration fraction for a molecule determined? What is the expected filtration fraction in a healthy individual?
By determining the ratio of the glomerular filtration rate to renal plasma flow; it is normally around 20%
• Prostaglandins are infused into a rat's renal arteries. What effects do they have on the glomeruli? What drug class can block them
They preferentially dilate afferent arterioles, increasing both the GFR and the RPF to keep the FF constant; NSAIDs
• Angiotensin II (AT II) is infused into a rat's renal arteries. What effects does it have on the glomeruli? What drug class can block it?
AT II preferentially constricts efferent arterioles, increasing GFR and decreasing RPF to increase FF; ACE inhibitors
• Prostaglandins ____ (increase/decrease) renal plasma flow and ____ (increase/decrease) glomerular filtration rate.
• ____ (Prostaglandins/Angiotensin II) alter(s) renal plasma flow and glomerular filtration rate such that filtration fraction is maintained.
Prostaglandins (increase both renal plasma flow and glomerular filtration rate) (inhibited by NSAIDs)
• In terms of filtration in the glomerulus, the filtered load is equal to the glomerular filtration rate multiplied by what?
The plasma concentration
• Angiotensin II ____ (increases/decreases) renal plasma flow and ____ (increases/decreases) glomerular filtration rate.
• A man takes an ACE inhibitor. How does its blockage of angiotensin II (AT II) affect the filtration factor (FF)?
FF decreases (renal plasma flow increases, and the glomerular filtration rate decreases)
• A man takes several capsules of extra-strength ibuprofen. What effect does this have on his afferent arterioles in his kidneys?
NSAIDs block prostaglandins' dilatory effect on afferent arterioles, thus his afferent arterioles constrict, which decreases GFR and RPF
• A patient's GFR is 125 mL/min, and RPF is 500 mL/min. What is the filtration fraction (FF)?
FF = GFR/RPF = (125 mL/min)/(500 mL/min) = 0.25 = 25%
• After a patient whose GFR is 125 mL/min takes a drug, a plasma concentration of 10 mg/mL is measured. What is the filtered load (mg/min)?
Filtered load = GFR × plasma concentration = 125 mL/min × 10 mg/mL = 1250 mg/min