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Flashcards in 131b malabsorption Deck (16):
1

what is the end result of malabsorbtion? what does that mean?

steatorrhea

loss of fecal fat (normally absorb 95%+)

2

what do bacteria do to bile salts? why does this matter?

deconjugate

wont form micelles

3

lactose deficiency?

most common disaccharidase deficiency

lactase isn't present

bacteria ferment lactose to form gas

short chain fatty acids are the preferred fuel of colon???

4

protein digestion - is acid required? what marks low protein absorption?

acid not required (hypochlorhydria)

low protein --> hypoalbuminemia --> edema

5

vit D deficiency symptoms?

osteoporesis; osteopenia

6

vit k deficiency symptoms?

bleeding

7

steatorrhea amount of fat/24hrs?

5 grams

8

where are bile salts absorbed?

terminal ileum

9

where is Fe absorbed?

duodenum

10

what is aborbed proximally?

iron
water soluble vitamins/minerals
fats, fat soluble vitamin (ADEK)
carbs, amino acids, small peptides

11

sudan stain

good specificity for steatorrhea, low sensitivty

stains fat - doesn't tell maldigestion vs malabsorption

12

schiling test - how is it done? what does various results mean?

B12 shot to saturate all sites + radioactive PO B12

R-protein + IF + B12 --> splitting off R-protein in order to absorb requires pancreas enzymes --> if bad pancreas then can't split off and absorb B12

measure how much comes out in urine
-if low then give IF to test; if corrects then pernicious anemia
-if corrects with pancreatic enzymes --> pancreatic insufficiency
-if corrects with antibiotics --> bacterial overgrowth
-never corrects --> ilieum resection/disease

13

CCK-Secretin duodenal drainage test

measure output following CCK and secretin admin

14

d-xylose - how is test done? what is normal? If abnormal, what does it indicate?

25 grams sugar PO that is passively absorbed in intestine

renal clearance (urine + blood test) should be > 5 grams

if < 5 grams --> malabsorption or bacterial overgrowth

15

early peak of hydrogen breath test?

bacterial overgrowth

16

small bowel bacterial overgrowth is indicated by what?

low serum B12
high serum folate