14: Metabolism Integration

Question 1

Three systems of ATP generation from fastest to slowest and timelines involved

Answer 1

1. ATP/Phosphagen system: 1-2 seconds of energy
2. Anaerobic glycolysis: next 30 seconds of activity
3. Aerobic respiration: long term energy

Question 2

How does the ATP/Phosphagen system work?

Answer 2

Regeneration of ATP by phosphocreatine

Question 3

Enzyme involved in ATP/Phosphagen system

Answer 3

Phosphocreatine kinase

Question 4

Where is phosphocreatine stored?

Answer 4

Muscles

Question 5

Fate of lactate from anaerobic glycolysis

Answer 5

Cori cycle: regeneration of glucose from lactate in the liver

Question 6

Leptin resistance

Answer 6

Similar to insulin resistance in that it is complex with many unknown factors, but it contributes to obesity

Question 7

SOCS

Answer 7

Suppressors of cytokine signaling: inhibit leptin and insulin receptors

Question 8

Three ways SOCS work

Answer 8

1. Bind receptor
2. Bind other signaling components
3. Enhance proteolytic degradation of receptors

Question 9

SOCS knockout mice

Answer 9

Enhanced sensitivity to leptin -> resistant to weight gain even on high fat diet