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Flashcards in 15 immune Responses To Microbes Deck (20):
1

Has thick peptidoglycan cell wall

Gram positive bacteria

2

Has lipopolysaccharide outermost membrane with thin perptidoglycan cell wall

Gram negative bacteria

3

Mechanisms of pathogenicity of bacteria

Pus formation
Endotoxin
Exotoxin

4

Components of bacterial wall

Endotoxin

5

Actively secreted by bacteria

Exotoxin

6

Complement activation by gram positive peptidoglycan in cell wall

C3 convertase

7

Member of the c-type lectins family of receptors that recognizes carbohydrates on the surface of microbes that facilitate their phagocytosis as well as stimulate subsequent adaptive immune response

Mannose receptors

8

Expressed on macrophages and mediate phagocytosis of microorganisms

Scavenger receptors

9

Recognition of bacteria opsonized with antibodies

Fc receptors

10

Caused by cytokines secreted by activated phagocytes
Induce leukocyte infiltration into infection site

Inflammatory response

11

Evasion mechanisms of bacteria

Antigenic variation
Inhibition of complement activation
Resistance to phagocytosis
Scavenging of oxygen intermediates

12

Enter through breach in the mucosa and skin
Introduced by vector
Can survive and replicate within phagocytes
Inaccessible to circulating antibodies
Requires cell mediated immunity

Intracellular bcteria

13

Produce IFN γ that activates macrophages

NK cells

14

Evasion mechanisms of intracellular bacteria

Inhibition of phagolysosome fusion
Inactivation of ROIs and nitrogen species
Disruption of phagosome membrane and escape into the cytoplasm

15

Principal mechanisms of innate immunity against viruses

Type 1 IFNs produced by leukocytes
NK cell mediated killing of infected cells

16

Evasion mechanisms of viruses

Latency
Antigenic variation

17

State of balance between persistent infection and immune response that can control the infection but not eradicate it

Latency

18

Small mutation in the epitopes of virus that help them escape destruction

Antigenic drift

19

Combination of different strains thus producing new strain

Antigenic shift

20

Innate immune response against parasites

Phagocytosis