15.0 Anticancer Flashcards Preview

Pharmacology > 15.0 Anticancer > Flashcards

Flashcards in 15.0 Anticancer Deck (17):
1

When are tumors first visible on X-ray?

10 to the 8th

2

What drugs acts only on G2 phase?

Bleomycin (antitumor antibiotic)

3

Each cycle of chemotherapy kills what percentage of cancer cells?

99% (2 log reductions)

4

Anticancer cells kill which rapidly dividing normal cells? Effects?

–Bone marrow: leads to neutropenia & thrombocytopenia

–GI mucosa: leads to mucositis & blisters

–Hair follicle: leads to alopecia

–Gonads: Infertility

5

Which drugs have a higher chance of causing secondary cancers?

procarbazine,
melphalan,
cisplatin

6

What are the adverse effects of Cyclophosphamide & Ifofamide

Hemorrhagic cystitis

7

AE of Bleomycin

Pulmonary fibrosis

8

AE of Cisplatin

Nephrotoxicity & Deafness

9

AE of Doxorubicin & Daunorubicin

Dilated cardiomyopathy

10

AE of Vincristine

Peripheral neuropathy

11

AE of Etoposide, Methotrexate & Vinblastine

Bonemarrow suppression

12

AE of L-Asparaginase

Pancreatitis and bleeding

13

Minimize Hemorrhagic cystitis by cyclophosphamide & ifosfamide

MESNA

14

Minimize Hemorrhagic cystitis by cyclophosphamide & ifosfamide

Good hydration and amifostine

15

Minimize Doxorubicin & daunorubicin induced dilated cardiomyopathy

Dexrazoxane

16

Mnimize Bonemarrow suppression by various drugs

Filgrastim (GM-CSF)

17

Minimize Methotrexate induced bonemarrow suppression

Leucovorin (Tetrahydrofolic acid)