16. Bone formation Flashcards Preview

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Flashcards in 16. Bone formation Deck (15)
1

Bone formation - types

1. endochondral ossification
2. membranous ossification

2

membranous ossification - which bones

.bones of calvarium and facial bones

3

endochondral ossification - which bones

bones of axial and appendicular skeleton and base of the skul

4

membranous ossification - mechanism

woven bone formed directly without cartilage . Later remodeled to lamellar bone

5

endochondral ossification - mechanism

Cartilaginous model of bone is first made by chondrocytes. Osteoclasts and osteoblast later replace with woven bone and then remodel to lamellar bone

6

woven bone is also called

fibrous bone

7

in adults woven bone occurs after

fractures and in Paget disease

8

smooth muscle contraction process

membrane depolarization ---> L-type voltagee gated Ca2+ channel --> increased intracellular Ca2+ ---> increased Ca2+ - calmodoulin complex --> activation of MLCK --> Myosin - p (+actin ) --> contraction ( via cross bridging)

9

• In bone formation, ____ ossification is responsible for long bone growth; ____ ossification is responsible for flat bone growth.

Endochondral; membranous

10

• In membranous ossification, ___ (woven/lamellar) bone is formed without cartilage and later remodeled to ___ (woven/lamellar) bone.

Woven, lamellar

11

• What role do osteoclasts and osteoblasts play in endochondral ossification?

They replace the cartilaginous model with woven bone and later remodel it into lamellar bone

12

• A man fractures his femur, which initially heals with what type of bone?

Woven bone

13

• Which bones are formed by endochondral ossification?

Bones of the axial and appendicular skeleton, as well as the base of the skull

14

• Which bones are formed by membranous ossification?

Bones of calvarium and face

15

• A patient is diagnosed with Paget disease of the bone. Histologically, what bone type will be seen on biopsy of a pathologic lesion?

Woven bone

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