Flashcards in 16. Bone formation Deck (15)
Bone formation - types
1. endochondral ossification
2. membranous ossification
membranous ossification - which bones
.bones of calvarium and facial bones
endochondral ossification - which bones
bones of axial and appendicular skeleton and base of the skul
membranous ossification - mechanism
woven bone formed directly without cartilage . Later remodeled to lamellar bone
endochondral ossification - mechanism
Cartilaginous model of bone is first made by chondrocytes. Osteoclasts and osteoblast later replace with woven bone and then remodel to lamellar bone
woven bone is also called
in adults woven bone occurs after
fractures and in Paget disease
smooth muscle contraction process
membrane depolarization ---> L-type voltagee gated Ca2+ channel --> increased intracellular Ca2+ ---> increased Ca2+ - calmodoulin complex --> activation of MLCK --> Myosin - p (+actin ) --> contraction ( via cross bridging)
• In bone formation, ____ ossification is responsible for long bone growth; ____ ossification is responsible for flat bone growth.
• In membranous ossification, ___ (woven/lamellar) bone is formed without cartilage and later remodeled to ___ (woven/lamellar) bone.
• What role do osteoclasts and osteoblasts play in endochondral ossification?
They replace the cartilaginous model with woven bone and later remodel it into lamellar bone
• A man fractures his femur, which initially heals with what type of bone?
• Which bones are formed by endochondral ossification?
Bones of the axial and appendicular skeleton, as well as the base of the skull
• Which bones are formed by membranous ossification?
Bones of calvarium and face