Flashcards in 18. Clinical Treatment of Heart Failure Deck (17):
How do diuretics treat HF?
reverse the Na and fluid retention
What diuretics are preferred and why?
loop diuretics bc of high potency
What do ACE inhibitors end in?
How do ACE inhibitors work?
Block conversion of ATI to ATII
What are the effects of ACE inhibitors?
Decreased aldosterone activation
What are the SE of ACE inhibitors?
Worsening renal function (afferent vasocontraction)
Cough (kinin potentiation)
Angiotensin receptor blockers (ARBs) end in?
What is the effect of Angiotensin receptor blockers (ARBs) ?
they block the receptor of angiotensin II
What are Angiotensin receptor blockers (ARBs) used for?
to replace ACE inhibitors (ie when cough develops)
What are the SE of Angiotensin receptor blockers (ARBs) ?
no kinin potentiation (no cough), otherwise same as ACE inhibitors:
Worsening renal function (afferent vasocontraction)Hyperkalemia
Name 2 aldosterone receptor blockers.
What are the effects of aldosterone receptor blockers?
block effect of aldosterone on the kidney
What are the SE of aldosterone receptor blockers?
What do the Beta-blockers end in?
What are the effects of Beta-blockers?
Antagonize effect of sypathetic system (epinephrine/norepinephrine)
• β1 blockade:
– Negative chronotrope (slow heart rate, less arrhythmia)
– Negative inotrope (decreased metabolic demand)
• [α1 blockade: vasodilation]
What are the SE of the Beta-blockers?
Negative inotrope: short-term loss for long-term gain
• Fluid retention
• Decreased cardiac output, even cardiogenic shock