18. Clinical Treatment of Heart Failure Flashcards Preview

CVPR Exam I > 18. Clinical Treatment of Heart Failure > Flashcards

Flashcards in 18. Clinical Treatment of Heart Failure Deck (17):
1

How do diuretics treat HF?

reverse the Na and fluid retention

2

What diuretics are preferred and why?

loop diuretics bc of high potency

3

What do ACE inhibitors end in?

- pril

4

How do ACE inhibitors work?

Block conversion of ATI to ATII

5

What are the effects of ACE inhibitors?

 Direct vasodilation
 Decreased aldosterone activation
 Other effects

6

What are the SE of ACE inhibitors?

Hypotension
 Worsening renal function (afferent vasocontraction)
 Hyperkalemia
 Cough (kinin potentiation)
 Angioedema

7

Angiotensin receptor blockers (ARBs) end in?

-sartan

8

What is the effect of Angiotensin receptor blockers (ARBs) ?

they block the receptor of angiotensin II

9

What are Angiotensin receptor blockers (ARBs) used for?

to replace ACE inhibitors (ie when cough develops)

10

What are the SE of Angiotensin receptor blockers (ARBs) ?

no kinin potentiation (no cough), otherwise same as ACE inhibitors:
Hypotension
Worsening renal function (afferent vasocontraction)Hyperkalemia
Angioedema

11

Name 2 aldosterone receptor blockers.

1. Spironolactone
2. eplerenone

12

What are the effects of aldosterone receptor blockers?

block effect of aldosterone on the kidney

antifibrotic

13

What are the SE of aldosterone receptor blockers?

hyperkalemia

14

What do the Beta-blockers end in?

-olol

15

What are the effects of Beta-blockers?

Antagonize effect of sypathetic system (epinephrine/norepinephrine)
• β1 blockade:
– Negative chronotrope (slow heart rate, less arrhythmia)
– Negative inotrope (decreased metabolic demand)
• [α1 blockade: vasodilation]

16

What are the SE of the Beta-blockers?

Negative inotrope: short-term loss for long-term gain
• Fluid retention
• Hypotension
• Decreased cardiac output, even cardiogenic shock
Bronchoconstriction

17

Name 2 electrical therapies for HFrEF?

1. implanted cardioverter defibrillators
2. cardiac resynchronization therapy/ biventricular pacemakers (CRT or BiV)