18 - Properties of the lung and airway resistance Flashcards

1
Q

a low compliance of the lungs means that the lungs are

A

stiff

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2
Q

pulmonary fibrosis causes what

A

scar forming fibrous connective tissue, reducing compliance of the lungs

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3
Q

what are some factors that can cause pulmonary fibrosis

A

tuberculosis, pneumonia, long term exposure to irritants

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4
Q

what are the two central concepts in relation to pulmonary elasticity

A

elastic recoil and compliance

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5
Q

the elasticity of lungs is due to two factors, what are there

A

pulmonary connective tissue has elastin fibres and THE ALVEOLAR SURFACE TENSION

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6
Q

what is the alveolar surface tension

A

thin liquid film lines each alveolus, surface tension - attractive force between surface water mols

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7
Q

an increasing alveolar surface tension causes a

A

decreased compliance of the lungs

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8
Q

what substance counteracts surface tension of water to prevent lung collapse

A

pulmonary surfactant

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9
Q

what does the pulmonary surfactant do to the compliance

A

increases it, decreasing the work required to inflate lungs

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10
Q

alveolar surface tension causes the SA to want to be as

A

small as possible

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11
Q

A decreased size in alveolus due to the alveolar surface tension adds to

A

elastic recoil

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12
Q

pulmonary surfactant is made of

A

phospholipoprotein

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13
Q

pulmonary surfactant decreases the tendency of lungs to

A

recoil which prevents lung collapse

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14
Q

newborn respiratory distress syndrome exists in foetal lungs because

A

PS is synthesised in late pregnancy

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15
Q

when there is no PS, there is high surface tension, causes alveoli

A

to collapse

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16
Q

what is the treatment for newborn respiratory distress syndrome

A

surfactant replacement and meds to help maturation process

17
Q

what is the main determinant in relation to resistance of airflow

A

radius of airway

18
Q

conducting airways always offer ____ resistance, can this be regulated?

A

low, no it isn’t regulated

19
Q

what part of the airways does have the radius regulated?

A

the bronchioles

20
Q

what is the primary factor in determining rate of airflow in normal healthy lungs?

A

pressure gradient

21
Q

bronchioles contain smooth muscle which is innervated by

A

the ANS

22
Q

when there is a low demand for airflow, the parasympathetic system kicks in causing

A

bronchoconstriction

23
Q

when there is an increased demand for o2 uptake by tissues, the sympathetic system kicks in + epinephrine causing

A

bronchodilation

24
Q

name an epinephrine related drug

A

salbutamol

25
Q

what is salbutamol selective for

A

b2-adrenergic agonist

26
Q

what does salbutamol cause

A

bronchodilation

27
Q

why is salbutamol used as therapy

A

counters airway restriction by causing bronchodilation