19 Opioids 1 Flashcards Preview

2 Pharm Unit > 19 Opioids 1 > Flashcards

Flashcards in 19 Opioids 1 Deck (34):
1

T/F endogenous opioid peptides exist?

True.

2

List the opioid receptors? What is their mechanism of action?

-mu, delta, kappa
-G-protein

3

How do opioids relieve pain?

Reduce sensitization due to injury

4

What are classic opioid side effects? (5) and less classic ones? (9) (just get familiar w/ them, not memorize)

-sedation
-constipation
-respiratory depression
-nausea
-vomiting

-euphoria, antitussive, inhibit sex hormone, miosis, itch, bradycardia, vasodilation, GI spasm, seizures

[generally: depresses pain, wakefulness, heart, lungs, & GI]

5

What is tolerance? Dependence?

-need greater dose
-physical:need dose or go into withdrawal. psych: "need" it

6

3 cardinal signs of opioid intoxication? (relate to the side effects)

respiratory depression, stupor/coma, miosis (constriction)

7

What does he want you to know about pain not managed by opioids?

we prescribe enough opioids but don't manage the psychological aspect of pain. Also opioids don't help much during physical activity

8

Analgesia definition?

absence pain w/o loss of consciousness

9

Narcotics defined legally? medically?

-Illegal
-opioid

10

Pain is due to?

tissue damage, directly related in intensity

11

what kind of pain med is most effective against motivation-affective pain?

Opioids!

12

What are the most efficacious pain meds?

Opioids!

13

What happens as opioid dose increases?

side effects exceed pain relief

14

T/F endogenous opioids are generally specific for 1 type of receptor (mu, delta, kappa)?

False. (he said "don't need to know which goes to which receptor for the test")

15

Mu receptors produce what functions? (integration "global" card, don't mem. list 8)

sedation, analgesia, dependence, respiratory depression, miosis, drops GI motility, vasodilation, euphoria

16

Kappa receptors produce what functions? (integration "global" card, don't mem. list 7)

analgesia, anticonvulsant, delirium, diuresis, dysphoria, miosis, sedation

17

Delta receptors produce what function? (global card don't mem. list 4)

analgesia, antidepressant, convulsant, physical dependence

18

What unique effect do delta receptors have? (2)

convulsant & antidepressant

19

What unique effect do kappa receptors have? (3)

anticonvulsant, delirium, dysphoria

20

What unique effect do mu receptors have? (4)

respiratory depression, euphoria, drops GI motility, vasodilation

21

T/F all 3 opioid receptors produce analgesia?

T

[note that mu and kappa receptors share similar effects like miosis, sedation, etc while the ONLY effect delta receptors have in common with the others is analgesia]

22

what kind of nociceptor do prostaglandins act on?

silent nociceptor

23

what kind of nociceptor does acid work on?

chemical nociceptor

24

Once opioid G-protein is triggered what does it do?

On excitatory neurons: Inhibit neurotransmission by blocking Ca influx presynaptically and increasing K efflux postsynaptically

25

What prevents respiratory depression?

intense pain

26

How are opioid side effects prevented?

anti-emetics & laxatives

27

What drug reverses opioid overdose?

Naloxone

28

What side effects do not become tolerant to opioids?

GI, ocular

29

Why is there no max dose of opioids?

tolerance to respiratory depression

30

Can a non-addicted person go thru withdrawal?

yes (they had physical but not psych dependence)

31

what does withdrawal look like?

sweaty, fast heart/BP, pain & can't sleep, squirting out both ends of GI tract

32

physical dependence is defined how?

withdrawal symptoms
[note: develops along w/ tolerance!!]

33

psych dependence is related to what neuro circuit?

mesolimbic dopamine

34

T/F addiction to acutely used opiods is rare?

True