2-1 Murrell-Lagnado Flashcards Preview

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Flashcards in 2-1 Murrell-Lagnado Deck (6)
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1
Q

Ether

A

Inhalation anaesthetic
High solubility in blood, slow induction and recovery
Respiration rate is limiting factor
High Kblood/gas - concs below what is needed for unconsciousness can still produce anaesthetic hangover

2
Q

Etomidate

A

IV anaesthetic
Metabolised rapidly
Target GABA-A receptor - prolong GABAergic IPSPs
More effective on receptors with B2 and B3 subunits

3
Q

Halothane

A

Inhalation anaesthetic
High blood solubility, slow induction and recovery
Respiration is limiting factor
Potentiation of GABA-A receptors
Potentiation of glycine receptors in medullary neurones
TREK-1 - 2 pore domain K channel also target

4
Q

Nitrous oxide

A

Inhalation anaesthetic
Low solubility in blood, fast induction and recovery
Limiting factor is cardiac output

5
Q

Propofol

A

IV anaesthetic
Metabolised rapidly
Target GABA-A receptor - prolong GABAergic IPSPs
Used for maintenance and induction of anaesthesia

6
Q

Thiopental / Thiopentone

A

IV anaesthesia
Barbiturate with high lipid solubility
Fast redistribution phase - diffuses out of high blood flow tissues into low blood flow tissues (fat)
Recovery of consciousness due to redistribution not elimination of drug
Intermediate phase - diffuses out of lean tissue but into fat
Terminal phase - most has accumulated in fat, some metabolised
Metabolised slowly, so prolonged effects