2 - Derm - Skin + Systemic disease - Cutaneous manifestations of malignancy Flashcards Preview

CP2 > 2 - Derm - Skin + Systemic disease - Cutaneous manifestations of malignancy > Flashcards

Flashcards in 2 - Derm - Skin + Systemic disease - Cutaneous manifestations of malignancy Deck (12):
1

Acanthosis nigricans
-describe skin
-where?

velvety, thickened, hyperpigmented skin

often in axillae, groin, neck, commonly with skin tags

2

Acanthosis nigricans
-ass w?

ass w insulin resistance, metabolic syndrome / T2DM, other endocrinopathies

ass w malignancy (GI) - suspect if sudden+severe

3

Acanthosis nigricans
--mgmt

treat underlying cause

4

Pyoderma gangrenosum
- describe

initial inflamed nodule, ulcerates and rapidly enlarges, often with necrotic centre, purply border, heals with cribriform (x-x) scar

5

Pyoderma gangrenosum
- when?
- where?

commonly after minor trauma/surgery, or spontaneous

commonly lower legs, buttocks, mucous membranes, peristomal sites

6

Pyoderma gangrenosum
- underlying conditions (present in 50% cases)

- UC/CD, infl arthritis, chronic hep, diverticulitis, malignancy 10% usually haematological

7

Pyoderma gangrenosum
- mgmt

corticosteroids (top/syst)
immsuppressants (ciclosporin, methotrexate)

8

Dermatomyositis
- cause?
- consequences?
- ass w?

infl of muscles in ass w skin rash
symmetrical proximal muscle weakness
only adult form is ass w malignancy (breast, lung, ovarian, colon, pancreas)

9

Dermatomyositis
- describe skin changes?
-distribution?

heliotrope (red/purple) rash - usually upper eyelids
Gottrons papules (flat violet) on bony prominences
nail fold changes

photosensitive distribution

10

Dermatomyositis
- Ix
- mgmt

i - muscle biopsy, electromyography, serum CK
mgmt - systemic corticosteroids, immsuppressants

11

Acquired icthyosis
- describe skin

dry scaly skin

12

Acquired icthyosis
- associations

possibly malignancy related
also - hypothyroidism, sarcoidosis, HIV

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