2 - Derm - Skin + Systemic disease - Drug eruptions 1 Flashcards Preview

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Flashcards in 2 - Derm - Skin + Systemic disease - Drug eruptions 1 Deck (9):
1

how many inpatients affected
common culprits..7

10%
ABx, NSAIDs, thaizides, ACEIs, OCP, allopurinol, anticonvulsants

2

Types of eruption - 4

toxic erythema
urticaria
fixed drug eruptions
erythema multiforme

3

Toxic erythema
-how common? - similar to?

most common eruption
like measles - morbilliform

4

Toxic erythema - features and assoc features, and when?

pruritic and erythematous maculopapular eruption on trunk

fever malaise, eosinophilia - often within 2 weeks of therapy

5

Toxic erythema - causes

penicillins - amox in glandular fever (almost 100%)0
cephalosporins
anticonvulsants

6

Urticaria - when? ass w? skin change?

rapid onset after drug
may be ass w angiooedema/anaphylaxis

wheals (transient pale papules with pink margins)

7

Urticaria - causes

penicillins and cephalosporins (T1HS via IgE)
Morphine and codeine (mast cell activation)

8

Fixed drug eruption - skin change? where and when?

circle oval red brown lesions , may ulcerate
in same location every time a drug is taken

9

Erythema multiforme is a ..?
list in order of increased severity

is a spectrum of conditions

erythema multiforme
stevens johnson syndrome
toxic epidermal necrolysis

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