2 - Gynae - Menstrual Cycle and its disorders - Precocious puberty + Ambiguous development and Intersex Flashcards Preview

CP2 > 2 - Gynae - Menstrual Cycle and its disorders - Precocious puberty + Ambiguous development and Intersex > Flashcards

Flashcards in 2 - Gynae - Menstrual Cycle and its disorders - Precocious puberty + Ambiguous development and Intersex Deck (9):
1

define precocious pub?
when is growth spurt? effect on final height? trt aims?

menstruation <10y/other 2' SCs <8
early - final height reduced
arrest sexual dev and allow normal growth

2

precocious puberty - mainstay of treatment? this medication causes what? what are the two general types of causes?

GnRH agonists
-inhibit sex hormone secretion and cause regression of 2' SCs and cessation of menstruation

central causes and ovarian/adrenal causes

3

central causes of precocious puberty

incr GnRH secretion:
-meningitis, encephalitis, CNS tumours, hydrocephaly, hypothyroidism

-may all prevent normal prepubertal inhibition of GnRH release

4

Ovarian/adrenal causes of precocious puberty - and mgmt?

incr oestrogen secretion:
-hormone prod tumours of ovary/adrenals
-mccune albright syndrome

remove tumour
Or
cyproterone acetate (antiandrogenic progestogen)

5

Ambiguous dev and intersex - 2 main reasons genitalia may be ambiguous?

incr androgen fx in a genetic female

red androgen fx in a genetic male

6

Incr androgen fx in genetic female - what is recessively inherited? what is defective? what does this cause?

CAH
defective cortisol prod
ACTH excess > incr androgen prod

7

Incr androgen fx in genetic female - when might they present? and with what? trt?

at birth - ambig genitalia
puberty - enlarged clit and amenorrhea

trt - cortisol and mineralocorticoid replacement

8

Red androgen fx in genetic male - male has cell receptor insensitivity - name? what happens to androgen? how does individual appear?

appears female

androgen insensitivity syndrome

they convert peripherally to oestrogens

9

Red androgen fx in genetic male - only diagnosed when..? what is absent and what is present? mgmt?

when presx with amenorrhea

uterus absent and rudimentary testes present

remove testes due to Ca risk
oestrogen HRT started

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