2. Pathogenesis of Periodontal Disease Lecture 1 MOD. Flashcards

1
Q

What are Cardinal Signs of Inflammation?

A
rubor
tumor
calor
dolor
functiolaesa (no function)
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2
Q

What causes acute inflammation?

A

Innate immunity

  • serum complement
  • neutrophil
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3
Q

What causes Chronic inflammation?

A

Acquired immunity

  • Macrophage
  • Lymphocytes
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4
Q

Describe clinical things of Initial Lesion?

A

Can’t see anything it looks healthy

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5
Q

Four stages of Infection?

A

Initial,
Early
Established
Chronic (Adv)

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6
Q

In Gingivitis what is the primary inflammatory cell that is present?

A

T lymphocytes

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7
Q

When do you have plasma cells constituting over 50%?

A

Periodontitis

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8
Q

WHen do you have plasma cell constituting to 10-30%?

A

Established gingivitis

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9
Q

Histamine

A

Increase of blood permeability

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10
Q

Chemotactic factors

A

PMN and Eosinophil

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11
Q

TNF alpha

A

induce fever (granulocytes)

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12
Q

Leukotrienes

A

bronchi constriction

Chemotaxis for leukocytes

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13
Q

Prostaglandins

A

Permeability

regulates immune response

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14
Q

When do Acute Phase Proteins (APC) decrease?

A

in response to inflammation

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15
Q

When do plasma proteins increase?

A

w/ microbial infection

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16
Q

What increases your case of a MI by 2-5 folds?

A

C-reactive protein

17
Q

PMN half-lifes are

A

short

18
Q

What attracts/causes E-selectin?

A

TNF alpha

19
Q

Azurophilic granules (primary granules)

A

Myeloperoxidase, BPI, Defensins, elastase and cathepsin G

20
Q

Specific granules (secondary granules)

A

anything you didnt memorzie

21
Q

Tertiary granules

A

Cathepsin, gelatinase

22
Q

List oxygen dependent PMN mechanisms… (3)

A

NADPH
Myeloperoxidase
superoxide disumatse
(LOOK FOR OXIDE)

23
Q

how many metalloproteinases are there?

A

17

24
Q

What are involved in periodontal tissue degradation?

A

Primary proteinases (MMP)

25
Q

Why are neutrophil proteases not thought to be a cause of tissue damage? (3)

A
  1. antiproteases
  2. latent inactive form
  3. anti-oxidants
26
Q

what can HOCl do?

A

inactivate the 3 major anti-proteases

27
Q

the two types of healthy gingiva are?

A

Pristine

Clinical

28
Q

in periodontitist what happens with the JE?

A

it turns into an ulcerated PE