Flashcards in 20. Important cytokines Deck (38):
Important cytokines secreted by macrophages
Il-1 6 8 12. TNFa
Importannt cytokines secreted by ALL T cells
Importannt cytokines secreted by Th1 cells
IFN - γ
Importannt cytokines secreted by Th2 cells
IL 4 5 10 13
IL - 1 AKA
osteoclast - activating factor
2. acute inflammation
IL-1 causes acute inflammation mechanism
1. activates endothelium to express adhesion molecules
2. Induce chemokine secretion to recruit WBCs
2. stimulates production of acute-phase proteins
4. Th --> TH17 (with il-6
major chemotacti factor for neutrophils
1. induce differentiation of T cells into Th1 cells
2. Activate NK cells
1. mediates septic shock
2. cachexia in malignancy
3. acute inflammation (WBC recruitment, activates endothelium, vascular leak)
4. Apoptosis (instrict pathway)
5. induce and maintains granuloma formation
stimulates growth of helper, cytotoxic and regulatory T cells an NK cells
supports growth and differentiation of bone marrow stem cells (function like GM-CSF)
INF- γ secreted by
NK cell and T cells in response to il-12 from macrophages
1. stimulates macrophages to kill phagocytosed pathogens
2. Ingibits differentiation of Th2
3. Activates NK cells to kill virus infected cells
4. Increases MHC expression an antigen presentation by all cells
1. induce differentiation of T-cells into Th2
2. Promotes growth of b cells
3. Inhibit Th1 differentiation
4. enhance class switching to IgE and IgG
1. Promotes growth and differentiation of B cells
2. Enhance clantiation of eosinophilsss switching to IgA
3. Stimulates growth and differe
1. attenuates inflammantory response
2. decreases expression of MHC II and Th 1 cytokines
3. Inhibits activated macrophages and dendritic cells
4. Inhibit differentiation of Th to Th1
beside Th2 cells, IL-10 is also secreted by
T reg cells
cytokines that attenuate the immune response
1. TGF- β
• What is the function of interleukin 1? By which type of cells is it secreted?
Causes fever/acute inflammation, activates endothelium to express adhesion molecules, and recruits WBCs via chemokine secretion; macrophages
What is another name for interleukin 1?
• What is the function of interleukin 2? By which type of cells is it secreted?
Stimulates growth of helper T cells, cytotoxic T cells, regulatory T cells, and NK cells; all secreted by T cells
• What is the function of interleukin 3? By which type of cells is it secreted? What signaling molecule does it function similarly to?
Growth and differentiation of stem cells in the bone marrow; secreted by activated T cells; functions similar to GM-CSF
• What is the function of interleukin 4? By which type of cells is it secreted?
Induces differentiation into Th2 cells, promotes growth of B cells, and enhances class switching to IgE and IgG; Th2 cells
• What is the function of interleukin 5? By which type of cells is it secreted?
Promotes differentiation of B cells, class switching to IgA, & growth/differentiation of eosinophils; Th2 cells
• What is the function of interleukin 6? By which type of cells is it secreted?
Stimulates production of acute-phase reactants and immunoglobulins; macrophages
• What is the function of interleukin 8? By which type of cells is it secreted?
Chemotaxis for neutrophils (aisle 8); macrophages
• What is the function of interleukin 10? By which type of cells is it secreted?
Modulates inflammation, decreases MHC class II/Th1 cytokine expression, inhibits active macrophages/dendritic cells; Th2/regulatory T cells
• What is the function of interleukin 12? By which type of cells is it secreted?
Induces differentiation of T cells into Th1 cells and activates NK cells; macrophages
• What is the function of interferon-γ? By which type of cells is it secreted?
Triggers macrophages to kill, induces NK cells to kill virus-infected cells, and promotes MHC expression/antigen presentation; Th1/NK cells
• What effect does interleukin 12 have on NK cells, from a cytokine perspective?
Triggers the release of interferon-γ
• Interferon-γ promotes MHC expression and antigen presentation by which cells?
• What is the function of tumor necrosis factor-#945;? By which type of cells is it secreted?
Mediates septic shock, activates endothelium, causes WBC recruitment and vascular leak, promotes cachexia in malignancy; macrophages
• Summarize the stimulatory effects of IL-1, IL-2, IL-3, IL-4, IL-5, and IL-6.
IL-1 = fever (hot), IL-2 = T cells, IL-3 = bone marrow, IL-4 = IgE, IL-5 = IgA, IL-6 = aKute-phase proteins (hot T-bone stEAK)
• Name the cytokines secreted by macrophages, all T cells, Th1 cells, and Th2 cells, respectively.
Tumor necrosis factor-α; IL-1, IL-6, IL-8, IL-12; IL-2, IL-3; interferon-γ; IL-4, IL-5, IL-10
• A woman has a fever. Which two cytokines secreted by macrophages likely contribute to this?
IL-1 and IL-6