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Flashcards in 20. Important cytokines Deck (38):
1

Important cytokines secreted by macrophages

Il-1 6 8 12. TNFa

2

Importannt cytokines secreted by ALL T cells

Il-2, Il-3

3

Importannt cytokines secreted by Th1 cells

IFN - γ

4

Importannt cytokines secreted by Th2 cells

IL 4 5 10 13

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IL - 1 AKA

osteoclast - activating factor

6

IL-1 causes

1. fever
2. acute inflammation
3. Cachexia

7

IL-1 causes acute inflammation mechanism

1. activates endothelium to express adhesion molecules
2. Induce chemokine secretion to recruit WBCs

8

IL 6

1. fever
2. stimulates production of acute-phase proteins
3. Cachexia
4. Th --> TH17 (with il-6

9

Il 8

major chemotacti factor for neutrophils

10

IL 12

1. induce differentiation of T cells into Th1 cells
2. Activate NK cells

11

TNF -a

1. mediates septic shock
2. cachexia in malignancy
3. acute inflammation (WBC recruitment, activates endothelium, vascular leak)
4. Apoptosis (instrict pathway)
5. induce and maintains granuloma formation

12

IL-2

stimulates growth of helper, cytotoxic and regulatory T cells an NK cells

13

IL-3

supports growth and differentiation of bone marrow stem cells (function like GM-CSF)

14

INF- γ secreted by

NK cell and T cells in response to il-12 from macrophages

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IFN-γ --->

1. stimulates macrophages to kill phagocytosed pathogens
2. Ingibits differentiation of Th2
3. Activates NK cells to kill virus infected cells
4. Increases MHC expression an antigen presentation by all cells

16

IL-4

1. induce differentiation of T-cells into Th2
2. Promotes growth of b cells
3. Inhibit Th1 differentiation
4. enhance class switching to IgE and IgG

17

Il-5

1. Promotes growth and differentiation of B cells
2. Enhance clantiation of eosinophilsss switching to IgA
3. Stimulates growth and differe

18

IL-10

1. attenuates inflammantory response
2. decreases expression of MHC II and Th 1 cytokines
3. Inhibits activated macrophages and dendritic cells
4. Inhibit differentiation of Th to Th1

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beside Th2 cells, IL-10 is also secreted by

T reg cells

20

cytokines that attenuate the immune response

1. TGF- β
2. IL-10

21

• What is the function of interleukin 1? By which type of cells is it secreted?






Causes fever/acute inflammation, activates endothelium to express adhesion molecules, and recruits WBCs via chemokine secretion; macrophages

22

What is another name for interleukin 1?

Osteoclast-activating factor

23

• What is the function of interleukin 2? By which type of cells is it secreted?


Stimulates growth of helper T cells, cytotoxic T cells, regulatory T cells, and NK cells; all secreted by T cells

24


• What is the function of interleukin 3? By which type of cells is it secreted? What signaling molecule does it function similarly to?


Growth and differentiation of stem cells in the bone marrow; secreted by activated T cells; functions similar to GM-CSF

25

• What is the function of interleukin 4? By which type of cells is it secreted?


Induces differentiation into Th2 cells, promotes growth of B cells, and enhances class switching to IgE and IgG; Th2 cells

26


• What is the function of interleukin 5? By which type of cells is it secreted?


Promotes differentiation of B cells, class switching to IgA, & growth/differentiation of eosinophils; Th2 cells

27

• What is the function of interleukin 6? By which type of cells is it secreted?


Stimulates production of acute-phase reactants and immunoglobulins; macrophages

28


• What is the function of interleukin 8? By which type of cells is it secreted?

Chemotaxis for neutrophils (aisle 8); macrophages

29

• What is the function of interleukin 10? By which type of cells is it secreted?


Modulates inflammation, decreases MHC class II/Th1 cytokine expression, inhibits active macrophages/dendritic cells; Th2/regulatory T cells

30


• What is the function of interleukin 12? By which type of cells is it secreted?


Induces differentiation of T cells into Th1 cells and activates NK cells; macrophages

31

• What is the function of interferon-γ? By which type of cells is it secreted?


Triggers macrophages to kill, induces NK cells to kill virus-infected cells, and promotes MHC expression/antigen presentation; Th1/NK cells

32


• What effect does interleukin 12 have on NK cells, from a cytokine perspective?


Triggers the release of interferon-γ

33

• Interferon-γ promotes MHC expression and antigen presentation by which cells?


All cells

34


• What is the function of tumor necrosis factor-#945;? By which type of cells is it secreted?


Mediates septic shock, activates endothelium, causes WBC recruitment and vascular leak, promotes cachexia in malignancy; macrophages

35

• Summarize the stimulatory effects of IL-1, IL-2, IL-3, IL-4, IL-5, and IL-6.


IL-1 = fever (hot), IL-2 = T cells, IL-3 = bone marrow, IL-4 = IgE, IL-5 = IgA, IL-6 = aKute-phase proteins (hot T-bone stEAK)

36


• Name the cytokines secreted by macrophages, all T cells, Th1 cells, and Th2 cells, respectively.

Tumor necrosis factor-α; IL-1, IL-6, IL-8, IL-12; IL-2, IL-3; interferon-γ; IL-4, IL-5, IL-10

37

• A woman has a fever. Which two cytokines secreted by macrophages likely contribute to this?


IL-1 and IL-6

38


• Transforming growth factor-β has the same attenuating effect on the immune system as which cytokine?


IL-10 (transforming growth factor-β and IL-10 both attenuate the immune response)