200's pharmo 2

Question 1

Benzodiazapines
lorazepam (Ativan)
diazepam (Valium)
midazolam (Versed)

acts on GABA A receptors potentiating the effects of GABA

Answer 1

lorazepam dose 0.5-2mg SIVP

diazepam dose 5-10mg SIVP

midazolam dose 1-2.5mg SIVP

Question 2

flumazenil (Anexate)

Benzo antagonist inhibiting actions of benzos on GABA

Answer 2

1st dose 0.2mg over 15 sec
2nd dose 0.3mg over 30 sec
3rd dose 0.5mg over 30 sec

Question 3

phenobarbital (Luminal)

• anticonvulsant
• sedative
• Barbiturate

Answer 3

-increase the action of inhibitory neurotransmitters

100-250 mg SIVP

Question 4

phenytoin (Dilantin)

• anticonvulsant
• sodium channel blocker
• promoting sodium efflux, stabilizing threshold

Answer 4

15-20mg/kg max 1000mg
requires 5 things
-blood work
-inline filter
-max 50mg/min
-must be in NS (no D5)

Question 5

haloperidol (Haldol)

• antipsychotic
• blocks dopamine receptors

Answer 5

2-5mg IM

Question 6

dimenhydrinate (Gravol)

-antiemetic

Answer 6

• works on the inner ear

- 12.5-50mg

Question 7

opioids 
morphine (Statex) 2-10mg SIVP
fentanyl (Sublimaze) 0.5-1 mcg/kg SIVP
meperidine (Demerol) 25-50mg SIVP
nalbuphine (Nubain) 5mg SIVP redose 2mg SIVP

Answer 7

morpine and nalbuphine act on opiate receptors

fentanyl and mepridine act on Mu receptors

Question 8

paralytics
non-depolarizing 
-pancuronium (Pavulon)  0.04-0.1 mg/kg
-rocuronium (Zemuron) 0.6-1.2 mg/kg
-vecuronoim (Norcuron) 0.08-0.1 mg/kg

depolarizing
succinylcholine (Anectine) 1-1.5 mg/kg

Answer 8

non-depolarizing
-competes with ACH to bind to cholinergic receptors (prevents form ACH binding to cholinergic receptors)

depolarizing
combines with cholinergic receptors causing depolarization and delaying repolarization

Question 9

neostigmine (Prostigmin)
-inhibits break down of ACH by acetylcholinesterase, ACH levels build up and allows for free transmission of nerve impulses

Answer 9

0. 5-2 mg SIVP

- pretreat with atropine

Question 10

ketamine (Ketalar) 0.5-1 mg/kg SIVP

Answer 10

dissociation of the limbic system and cortex