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Flashcards in 2012 Block A Deck (92)
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1

Splenectomy offers a clinical cure in:
a. Autoimmune Hemolytic Anemia
b. Hereditary Spherocystosis
c. Thalassemia Major
d. G6PD Deficiency

B

2

The definitive diagnostic procedure for Thalassemia is:
a. Coomb’s Test
b. Osmotic Fragility Test
c. Hemoglobin Electrophoresis
d. Ham’s Test

C

3

In the presence of prolonged neonatal jaundice, with exposure to naphthalene balls, one should consider:
a. G6PD Deficiency
b. Autoimmune Hemolytic Anemia
c. Thalassemia Major
d. Neonatal Hepatitis Syndrome

A

4

This hemoglobin is markedly increased in Beta Thalassemia Major:
a. HbA1
b. HbA2
c. HbH
d. HbF

B & D

5

The definitive diagnostic procedure for Hereditary Spherocytosis is:
a. Coomb’s Test
b. Osmotic Fragility Test
c. Ham’s Test
d. Hemoglobin Electrophoresis

B

6

The aim of hypertransfusion and supertransfusion in Thalassemia Major is:
a. To increase the patient’s iron stores
b. To increase the patient’s serum iron
c. To improve the patient’s anemia
d. To suppress erythropoiesis in the marrow

D

7

Patient with hemolysis, cranio facial changes, with frequent blood transfusions and stunted growth:
a. Is a silent carrier
b. Has a thalassemia trait
c. Has thalassemia intermedia
d. Has thalassemia major

D

8

Why is crossmatching done before transfusion?
a. To detect alloantibodies present in the recipient
b. To prevent alloimmunization
c. To detect alloantibodies in the recipient
d. To prevent sensitization of the patient

B

9

The 4 allele deletion in Alpha Thalassemia that is incompatible with life is:
a. Silent Carrier
b. Thalassemia Trait
c. Hemoglobin H Disease
d. Hydrops Fetalis

D

10

At birth fetal red cells contain 53 to 95%:
a. HbA1
b. HbA2
c. HbH
d. HbF

D

11

What risk do neonates have when they receive directed donations from first degree relatives:
a. Acute hemolytic reaction
b. Transfusion-associated GVHD
c. Febrile reaction
d. Allergic reaction

B

12

Which one is not an indication for exchange transfusion in neonates?
a. Rh incompatibility
b. Iron Deficiency Anemia
c. ABO incompatibility
d. Sepsis

B

13

Which statement is not true regarding transfusion in neonates?
a. The antibody-producing mechanisms and cellular immune system of neonates are mature.
b. Hypothermia in the newborn causes adverse metabolic effects.
c. Transfusion in neonates is different and unique.
d. The newborn does not compensate for hypovolemia as well as an adult.

A

14

Most common cause of fatal transfusion reactions worldwide:
a. Clerical error
b. Transfusion related acute lung injury
c. Congestive heart failure secondary to overload
d. Febrile non-hemolytic transfusion reaction

A

15

Reason/s to temporarily defer a blood donor from donating blood:
a. Ear piercing within 6-12 months
b. Major surgery 5 years ago
c. Chemotherapy for Hodgkin’s Lymphoma 5 years ago, patient in remission
d. History of treated venereal disease

A & D

16

Indication to irradiate blood:
a. Third degree relative blood donor
b. History of frequent allergic reactions to blood transfusion
c. History of febrile non-hemolytic transfusion reactions
d. Blood donor with history of asthma

A

17

These tests may be most informative in diagnosing Paroxysmal Nocturnal Hemoglobinuria:
a. Ham’s Test and Sucrose Lysis Test
b. Immunophenotyping and FISH
c. Erythropoietin Assay and Coomb’s Test
d. Chromosomal Analysis

A

18

Mechanism of action of Cyclosporine in Aplastic Anemia:
a. Reduces cytotoxic T cells
b. Inhibits interleukin 2 production by T lymphocytes
c. Modulates adverse reactions to ATG
d. Stimulate production of erythropoietin

D

19

Site of maximum iron absorption:
a. Stomach
b. Duodenum
c. Distal ileum
d. Colon

B

20

A 6 year old child with 4 year history of easy bruisability is brought to PGH with multiple purpuras on both shins and forearms. The rest of the PE is unremarkable. You think it is normal bruising of childhood, but the parents are concerned. If bleeding is spontaneous, what would you expect to see?
a. Bruise out of proportion to degree of trauma
b. Bleeding from a cut lasting 30 seconds
c. Hematomas after immunizations
d. A and C

D

21

You decide to order screening tests. Which one will you order?
a. CBC, Platelets, Clotting Time, Bleeding Time, Clot Retraction Time
b. CBC, Platelets, Prothrombin Time, Partial Thromboplastin Time
c. CBC, Platelets, Bleeding Time
d. CBC, Platelets

B

22

Hemophilia A is:
a. X-Linked
b. Autosomal Dominant
c. Autosomal Recessive
d. Not a familial disease

A

23

15 year old boy with LLQ pain; HR 120 bpm; BP 80/60. Family history includes 2 uncles who died of a bleeding disorder. Your differential diagnosis would include the following except:
a. Acute appendicitis
b. Urinary Tract Infection
c. Iliopsoas Bleed
d. Acute Peptic Ulcer Disease

D

24

Your primary working impression is:
a. Von Willebrand Disease
b. Platelet Function Defect
c. Acute Immune Thrombobytopenic Purpura
d. Hemophilia A

D

25

Management would include the following except:
a. FWB transfusion
b. Cryoprecipitate
c. Platelet concentrate transfusion
d. Pain medication

D

26

Which of the following is true about hemophilia?
a. Clinical features of Hemophilia A and B are indistinguishable
b. Mild hemophilia would present with spontaneous bleeding
c. Gum bleeds and epistaxis occur in hemophilia
d. There is no such thing as a female hemophilia

A

27

Which of the following will present with a decreased Platelet, prolonged Prothrombin Time, prolonged Partial Thromboplastin Time?
a. Acute Immnue Thrombocytopenic Purpura
b. Disseminated Intravascular Coagulation
c. Hemophilia
d. Vitamin K Deficiency

B

28

Which among the following is consistent with a platelet type of bleeding?
a. Local measures are effective to stop the bleeding
b. Bleeding may last for days
c. Bleeding within the muscles is often
d. Hemarthrosis is common

A

29

Liver disease can impair hemostasis and cause bleeding by which of the following mechanism?
a. Increase levels of intrinsic pathway inhibitor
b. Dysfibrinogenemia
c. Increase levels of anti-thrombin III
d. Marked thrombocytosis

B

30

Which characterizes bone marrow with AITP?
a. Presence of marked reticulin formation
b. Megakaryoctes increased
c. Cellularity of bone marrow decreases
d. Presence of atypical non-hematologic cell

B