Flashcards in 2017 Biochemistry - Oxidation of Pyruvate and TCA Cycle Deck (11):
Where does the pyruvate dehydrogenase complex "live" in the cell?
Inside the mitochondrion
How many enzymes and cofactors are involved in the PDH Complex?
Where does the TCA cycle take place?
Matrix of Mitochondria
What are the inputs and outputs of the TCA cycle?
What are the irreversible steps of TCA cycle and which enzymes are involved?
Step 1: Citrate Synthase
Step 6: a-Ketoglutarate dehydrogenase complex
What is the rate limiting step of TCA cycle? What is produced at this step?
Produces first NADH and first CO2
What inhibits Citrate synthase?
What stimulates and inhibits Isocitrate Dehydrogenase?
What inhibits a-KGDH?
Inhibits: Succinyl-CoA, NADH, GTP
What is the purpose of the pyruvate dehydrogenase multienzyme complex?
Oxidatively decarboxylate pyruvate into Acetyl-CoA