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Flashcards in 20_Cell Junctions Deck (18)
1

From apical to basal, what is the order of junctions in the junctional complex?

Tight junctions (zonula occuldens)
Adherens junctions
Desmosomes (macula adherens)

2

At which junction are the membranes of two cells closest together?

tight junctions

3

The blood brain barrier is an example of which junction?

tight junctions

4

What is an example of a tight junction protein that if mutated, results in dehydration?

claudin-1

5

Which junctions contribute to cell polarity?

tight junctions form barriers that block protein movement

6

Adherens junctions connect the external environment with the ______ cytoskeleton.

actin

7

What is an example of an adherens junction protein?

cadherin

8

Which adapter proteins link cadherins in adherens junctions to actin filaments?

catenins (ß-catenin, a-catenin, p120 catenin)

9

Desmosomal cadherins anchor to _________.

keratin intermediate filaments

10

Which adapter proteins allow anchoring of desmosomal cadherins to keratin?

plakoglobin, desmoplakin, plakophillin

11

What are two desmosomal cadherins?

desmoglein, desmocollin

12

How do connexin proteins form gap junctions?

6 connexins form a connexon (transmembrane channel with central pore)
2 connexons form a gap junction

13

Gap junctions provide hydro (philic/phobic) channels.

hydrophilic

14

Which junctions connect cells to the ECM?

hemidesmosomes & focal adhesions

15

Which cytoskeleton do focal adhesions interact with?

keratin

16

Which cell-substratum interactions are involved in cell motility and survival signalling?

focal adhesions

17

In focal adhesions, what do ECM proteins do cellular integrins interact with?

collagen and fibronectin

18

In hemidesmosomes, which anchoring protein do the cell's integrins interact with on the ECM side?

laminin