Flashcards in 20_Cell Junctions Deck (18)
From apical to basal, what is the order of junctions in the junctional complex?
Tight junctions (zonula occuldens)
Desmosomes (macula adherens)
At which junction are the membranes of two cells closest together?
The blood brain barrier is an example of which junction?
What is an example of a tight junction protein that if mutated, results in dehydration?
Which junctions contribute to cell polarity?
tight junctions form barriers that block protein movement
Adherens junctions connect the external environment with the ______ cytoskeleton.
What is an example of an adherens junction protein?
Which adapter proteins link cadherins in adherens junctions to actin filaments?
catenins (ß-catenin, a-catenin, p120 catenin)
Desmosomal cadherins anchor to _________.
keratin intermediate filaments
Which adapter proteins allow anchoring of desmosomal cadherins to keratin?
plakoglobin, desmoplakin, plakophillin
What are two desmosomal cadherins?
How do connexin proteins form gap junctions?
6 connexins form a connexon (transmembrane channel with central pore)
2 connexons form a gap junction
Gap junctions provide hydro (philic/phobic) channels.
Which junctions connect cells to the ECM?
hemidesmosomes & focal adhesions
Which cytoskeleton do focal adhesions interact with?
Which cell-substratum interactions are involved in cell motility and survival signalling?
In focal adhesions, what do ECM proteins do cellular integrins interact with?
collagen and fibronectin