21. Osteomalacia/rickets Flashcards Preview

Muskoloskeletal > 21. Osteomalacia/rickets > Flashcards

Flashcards in 21. Osteomalacia/rickets Deck (13)
1

Vitamin D deficiency can cause

adults --> osteomalacia ( defective mineralization of osteoid)
children --> rickets ( defective mineralization of cartilaginous growth plates )

2

Vitamin D deficiency --> condition of boones ( mechanism

Vitamin D deficiency --> defective mineralization / calcification of osteoid --> soft bones that bow out

3

Vitamin D deficiency - serum P level ( mechanism

decreased vitamin D --> decreased serum Ca2+ --> increased PTH secretion --> DECREASED SERUM Pi

4

Vitamin D deficiency - Ca2+

low

5

Vitamin D deficiency - ALP level ( why)

increased ALP 9 because of osteoblast hyperactivity - osteoblasts require alkaline environment )

6

osteomalacia - x rays

osteopenia and looser zones ( pseudofractures _

7

rickets - x-rays

epiphyseal widening and metaphyseal cupping / fraying

8

children with rickts presentation

bow legs . bead - like costochondreal jucntions
(rachitic rosary craniotabes ( soft skull )

9

• What disorder is caused by defective mineralization of osteoid leading to soft bones?

Osteomalacia/rickets

10

• A 2-year-old child has bowing of his legs. His labs show elevated PTH levels but decreased Ca2+ levels. What is the primary deficiency?

Vitamin D (this child has rickets)

11

• A patient is diagnosed with osteomalacia. What is the pathophysiology of this condition?

High PTH decreases serum phosphate, causing demineralization/soft bones (low vitamin D leads to low serum calcium, triggering PTH secretion)

12

• Parathyroid hormone is increased in osteomalacia, which activates what type of cell to produce what enzyme?

Osteoblasts are stimulated to make alkaline phosphatase, because they need an alkaline environment to function properly

13

• Which of the following diseases are essentially the same: osteoporosis, osteomalacia, osteopetrosis, rickets?

Osteomalacia and rickets are the same disease, but rickets is the term for the childhood form

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