Flashcards in 22. Juxtaglomerular apparatus Deck (9):
Juxtaglomerular apparatus consist of
1. mesangial cells
2. JG cells ( modified SMCs of afferent arteriole)
3. Macula densa ( part of DCT)
Macula densa - function
NaCL sensor in DCT --> if low -> increase renin secretion --> efferent arteriole vasoconstriction --> increases GFR
JGA maintain GFR via
β-blockers can decrease BP by inhibiting β1 receptrors of the juxtraglomerular apparatus --> decrease renin release
• Juxtaglomerular cells in the juxtaglomerular apparatus are modified smooth muscle cells of what arteriole of the glomerular vasculature?
The afferent arteriole
• What effect will decreased NaCl delivery to the DCT have on the macula densa cells and juxtaglomerular apparatus?
Decreased NaCl leads to adenosine release and afferent arteriole vasoconstriction
• Name at least two triggers of renin release by the juxtaglomerular cells.
Decrease in renal blood pressure, decrease in sodium delivery to the distal tubule, increase in sympathetic tone (β1)
• What are the results of renin release by the juxtaglomerular cells?
Angiotensin II and aldosterone levels increase, leading to increased NaCl retention, circulating volume, and blood pressurε