22. Juxtaglomerular apparatus Flashcards Preview

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Flashcards in 22. Juxtaglomerular apparatus Deck (9):

Juxtaglomerular apparatus consist of

1. mesangial cells
2. JG cells ( modified SMCs of afferent arteriole)
3. Macula densa ( part of DCT)


Macula densa - function

NaCL sensor in DCT --> if low -> increase renin secretion --> efferent arteriole vasoconstriction --> increases GFR


JGA maintain GFR via

renin-angiotensin-aldosterone system


β-blockers -BP

β-blockers can decrease BP by inhibiting β1 receptrors of the juxtraglomerular apparatus --> decrease renin release


• Juxtaglomerular cells in the juxtaglomerular apparatus are modified smooth muscle cells of what arteriole of the glomerular vasculature?

The afferent arteriole


• What effect will decreased NaCl delivery to the DCT have on the macula densa cells and juxtaglomerular apparatus?

Decreased NaCl leads to adenosine release and afferent arteriole vasoconstriction


• Name at least two triggers of renin release by the juxtaglomerular cells.

Decrease in renal blood pressure, decrease in sodium delivery to the distal tubule, increase in sympathetic tone (β1)


• What are the results of renin release by the juxtaglomerular cells?

Angiotensin II and aldosterone levels increase, leading to increased NaCl retention, circulating volume, and blood pressurε


• A patient starts taking a β-blocker. Later, serum levels of renin are noted to be unusually low. Why is this the case?

β1-receptor activity stimulates renin release, which the new β-blocker is likely interfering with

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