22. Paget disease of bone (osteitis deformans) Flashcards Preview

Muskoloskeletal > 22. Paget disease of bone (osteitis deformans) > Flashcards

Flashcards in 22. Paget disease of bone (osteitis deformans) Deck (22)
1

Paget disease of bone is also called

osteitis deformans

2

Paget disease of bone ( osteitis deformans ) - frequenxy

common

3

Paget disease of bone ( osteitis deformans - localized or general

localized

4

Paget disease of bone (osteitis deformans ) - pathophysiology

LOCALIZED disorder of bone remodeling caused by increased in both osteoblastic and osteoclastic activity

5

Paget disease of bone - Ca2+ levels

normal

6

Paget disease of bone - Pi levels

normal

7

Paget disease of bone - PTH levels

normal

8

Paget disease of bone - ALP

increased

9

Paget disease of bone - increaased risk of

osteogenic sarcoma

10

Vitamin D deficiency is seen with

1. decreased sun exposure
2. liver failure
3. malabsorption
4. poor diet
5. renal failure

11

Paget disease of bone - etiology

unknown
probably viral

12

Paget disease of bone - increased risk for

osteogenic sarcoma

13

Paget disease of bone - clinical presentation

1. increased hat size
2. hearing loss
3. high output cardiac fialure
4. long bone chalk - stick fractures

14

Paget disease of bone - mechanism of hearing loss

auditory foramen narrowing

15

Paget disease of bone - mechanism of cardiac failure

increased formation fo arteriovenous shunts

16

Paget disease of bone - architecture

Mosaic pattern of woven and laellar bone pp> osteocytes with lacunae in chaotic juctapositions

17

Paget disease of bone - stages ( and process)

1. Lytic - osteoclasts
2. Mixed - osteoclasts and osteoblasts
3. Sclerotic - osteoblasts
4. Quiescent - minimal osteoclast / osteoblst activity

18

• A patient has increased osteoblastic and osteoclastic activity with normal calcium, phosphate, and PTH levels. What disease stage is this?

This is the mixed stage of Paget disease of the bone (osteitis deformans), with increases in both osteoblast and osteoclast activity

19

• A man with an increasing hat size and progressive hearing loss suffers a long bone fracture. What enzyme do you expect to be elevated?

Alkaline phosphatase (this patient has Paget disease of bone [osteitis deformans])

20

• If a man complains of worsening hearing, increased hat size, and heart failure all due to the same disease, he is at risk of what cancer?

Osteogenic sarcoma, the risk for which is higher in Paget disease of bone (osteitis deformans)

21

• What happens to levels of calcium, phosphate, parathyroid hormone, and alkaline phosphatase in Paget disease of the bone?

Calcium, phosphate, and parathyroid hormone levels are normal, and ALP levels are increased

22

• What are the four main stages of Paget disease of the bone (osteitis deformans) and the defining characteristic of each one?

Lytic (osteoclasts only), mixed (osteoclasts/osteoblasts), sclerotic (osteoblasts only), and quiescent (low osteoblast/osteoclast activity)

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