23. Kidney endocrine functions Flashcards Preview

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Flashcards in 23. Kidney endocrine functions Deck (9):
1

hormones produce by kidney (nwhich hormones are from where exactly )

1. renin --> from Juxtra glomrtular apparatus
2. erypthropoietin --> from interstitial cells in peritubular capillary bed
3. Prostagladins --> paracrine in afferent arterioles
4. Calcitriol ( 1.25 OH 2 vitamine D3 - active form ) ---> from PCT cells
5. Dopamine --> from PCT cells

2

erythropoietin is released by .... in response to

interstitial cells in peritubular capillary bed in response to hypoxia

3

Erythropoietin - function

stimulates RBCs proliferation in bone marrow

4

erythropoietin - clinical use as a drug

chronic kidney disease

5

kidney - calcitriol

PCT cells convert 25-OH vitamin D3 to 1.25 (OH) 2 vitamin D3 ( calcitriol , active form) via PARATHORMONE ACTION ( increases 1α- hydroxylase )

6

kidney - prostagladins action and secretion

paracrine secretion vasodiates the afferent arterioles to increase RBF

7

effect of NSAID on renal function

NSAIDS inhibit prostaglandins ( that preferentially dilated afferent arteriole and increase RPF and GFR , not the FF )
--> constriction of afferent arteriole ---> decrease of RPF and GFR , no the FF --> IN LOW RENAL BLOOD STATES --> ACUTE RENAL FAILURE

8

kidney - dopamine is secreted by

PCT cells

9

kidney - dopamine action

- Promotes natriuresis
- at low doses --> dilates interlobular arteries, afferent arterioles and efferent arterioles ---> increased RBF , little or no change in GFR
-at higher doses --> acts vasoconstrictor

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