23. Neuroblastoma Flashcards Preview

Endocrine > 23. Neuroblastoma > Flashcards

Flashcards in 23. Neuroblastoma Deck (28):
1

MC tumor of adrenal medulla in children

neuroblastoma

2

neuroblastoma - age

usually less than 4

3

neuroblastoma - originates from

neural crest cwlla

4

neuroblastoma - genes

overexpression of N-myc

5

neuroblastoma - histology

1. Horner - Wright rosettes
2. classic small, round, blue/purple nuclei

6

Horner - Wright rosettes definition / which tumors

type of rosette in which diffrerentiated tumor cells surround the neurophil ( area composed of mostly unmyelinated axons, dendrites and glial cell )
1. Neuroblastoma
2. medulloblastoma
3. pinealoblastoma

7

area

occures anywhere along the sympathetic chain

8

neuroblastoma - hypertension

rarely ( less likely than pheochromocytoma )

9

neuroblastoma labs in urine

1. increased homovalinic acid ( product of dopamine ) in urine
2. increased vanillymandelic acid ( VMA, product of norepinephrine ) in urine
3. bobesin positive
4. neuron enolase positive ( NSE)

10

neuroblastoma labs - positive enzymes

3. bobesin positive
4. neuron enolase positive ( NSE)

11

most common prensetation

1. abdomina distension
2. firm , irregular mass that cross the midline

12

neuroblastoma vs wilms tumor ( presentation )

neuroblastoma: firm irregular mass that cros the midline
wilms tumor : smooth and unilateral mass

13

neuroblastoma - ALSO present with

opsoclonus - myoclonus syndrome ( ' dancing eyes- dancing feet")

14

opsoclonus definition

uncontrelled eye mocement ( dancing eyes)

15

neuroblastoma vs pheochromocytoma : N- myc overexpression

neuroblastoma

16

neuroblastoma vs pheochromocytoma : von Hippel- Lindau disease

pheochromocytoma

17

pheochromocytoma is associated with

1. neurofibromatosis type 1
2. von Hippel -Lindau disease
3. MEN 2A
4. MEN 2B

18

neuroendocrine tumors ?

group of neoplasmas originating from Kulchitsky and enterochromaffin like cells

19

neuroendocrine tumors are group of neoplasms originating from

ulchitsky and enterochromaffin like cells

20

Neuroendocrine tumors - organs

1. thyroid : medullary
2. lungs : small cell
3. pancreas: islet cell tumor
4. adrenals : pheochromocytoma

21

Neuroendocrine tumors - cell contain / behavaiour

cells contain amine precursor uptake decarboxylase ( APUD) and secrete different hormones:
1. chromogranin 2. neuro-specific enolase ( NSE)
3. 5-HIAA

22

Neuroblastoma is classified as an

amine precursor uptake decarboxylase (APUD) tumor

23

The most common adrenal tumor is ____ in adults and ____ in children. Patients with ____ are less likely to develop hypertension.

Pheochromocytoma; neuroblastoma; neuroblastoma

24

Where in the body can a neuroblastoma develop?

Anywhere along the sympathetic chain, usually as a firm, irregular mass that can cross the midline (unlike smooth, unilateral Wilms tumors)

25

What oncogene is associated with rapid neuroblastoma tumor progression?

N-myc oncogene

26

Which of these cancers is bombesin negative: neuroblastoma, small cell lung cancer, gastric carcinoma, melanoma, pancreatic carcinoma

Melanoma (bombesin is a marker for the others)

27

A 6-month-old boy with bizarre eye movements and lower-extremity muscle jerking is found to have an abdominal mass. Most likely diagnosis?

Neuroblastoma presenting with opsoclonus-myoclonus syndrome ("dancing eyes–dancing feet")

28

A pathologist asks: "From what cell line did a tumor staining positively for Bombesin, neuron-specific enolase, and chromogranin come?"

Neural crest cells