23. Pancreatic secretions Flashcards Preview

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Flashcards in 23. Pancreatic secretions Deck (16):
1

a- amylase

Starch digestion

2

a- amylase secreted in active/inactive form

active

3

Lipases

Fat digestion

4

Proteases

Protein digestion

5

Proteases Includes

Includes trypsin, chymotrypsin, elastase,
carboxypeptidases

6

Protease Secreted as

Secreted as proenzymes also known as
zymogens

7

Trypsinogen- activation
Converted to trypsin by

enterokinase/
enteropeptidase, a brush-border enzyme on
duodenal and jejunal mucosa

active enzyme trypsin
--> activation of other proenzymes and cleaving
of additional trypsinogen molecules into active
trypsin (positive feedback loop)

8

• A patient with decreased α-amylase may have impaired digestion of what type of food material?

Starch

9

• Lipase, phospholipase A, and colipase function primarily in what general digestive process?

Fat digestion

10

• Proteases help digest protein. Name the major proteases secreted by the pancreas.

Trypsin, chymotrypsin, elastase, and carboxypeptidase

11

• Are proteases secreted in active or inactive forms?

Inactive forms (called proenzymes or zymogens)

12

• Which pancreatic enzyme converts trypsinogen to trypsin?

Enterokinase/enteropeptidase (on the duodenal and jejunal brush border)

13

• After being converted to its active form in the intestinal lumen, trypsin then does what?

It activates the other proenzymes as well as more trypsin molecules

14

• For the pancreas, low flow of secretions results in high levels of ____, whereas high flow of secretions results in high levels of ____.

Cl-; HCO3-

15

• Are pancreatic secretions hypotonic, isotonic, or hypertonic?

Isotonic

16

• A man eats a large amount of popcorn at a movie. What critical enzyme is released in its active form to digest this?

α-amylase

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