Flashcards in 23. Pancreatic secretions Deck (16):
a- amylase secreted in active/inactive form
Includes trypsin, chymotrypsin, elastase,
Protease Secreted as
Secreted as proenzymes also known as
Converted to trypsin by
enteropeptidase, a brush-border enzyme on
duodenal and jejunal mucosa
active enzyme trypsin
--> activation of other proenzymes and cleaving
of additional trypsinogen molecules into active
trypsin (positive feedback loop)
• A patient with decreased α-amylase may have impaired digestion of what type of food material?
• Lipase, phospholipase A, and colipase function primarily in what general digestive process?
• Proteases help digest protein. Name the major proteases secreted by the pancreas.
Trypsin, chymotrypsin, elastase, and carboxypeptidase
• Are proteases secreted in active or inactive forms?
Inactive forms (called proenzymes or zymogens)
• Which pancreatic enzyme converts trypsinogen to trypsin?
Enterokinase/enteropeptidase (on the duodenal and jejunal brush border)
• After being converted to its active form in the intestinal lumen, trypsin then does what?
It activates the other proenzymes as well as more trypsin molecules
• For the pancreas, low flow of secretions results in high levels of ____, whereas high flow of secretions results in high levels of ____.
• Are pancreatic secretions hypotonic, isotonic, or hypertonic?