24.Lab values in bone disorders Flashcards Preview

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Flashcards in 24.Lab values in bone disorders Deck (45)
1

Osteoporosis - serum Ca2+

normal

2

Osteoporosis - Pi

normal

3

Osteoporosis - ALP

normal

4

Osteoporosis -PTH

normal

5

Osteopetrosis - PTH

normal

6

Osteopetrosis -ALP

normal

7

Osteopetrosis -PI

normal

8

Osteopetrosis - serum Ca2+

normal / decreased

9

Osteopetrosis - serum Ca2+ - when is decreaed

in severe malignant disease

10

Paget disease of bones ( osteitis deformans ) - serum Ca2+

normal

11

Paget disease of bones ( osteitis deformans ) -Pi

normal

12

Paget disease of bones ( osteitis deformans ) - ALP

increased

13

Paget disease of bones ( osteitis deformans ) - PTH

normal

14

osteomalacia / rickets - serum Ca2+

low

15

osteomalacia / rickets - Pi

low

16

osteomalacia / rickets -ALp

increased

17

osteomalacia / rickets - PTH

increased

18

caused of hypervitaminosis D

1. oversupplementation
2. granulomatous disease

19

hypervitaminosis D - Pi

increased

20

hypervitaminosis D - ALP

normal

21

hypervitaminosis D -PTH

low

22

hypervitaminosis D - serum Ca2+

inreased

23

Primary Hyperpatathyroidism causes

osteitis fibrosa cystica

24

primary hyperparathyroidism is caused by

1. idiopathic
2. parathyroid hyperplasia
3. parathryoid adenoma
4. parathyroid carcinoma

25

osteitis fibrosa cystica is also called ( why )

brown tumor
because its is filled with brown

26

osteitis fibrosa cystica causes ( appearance )

subperiosteal thinning

27

primary hyperparathyroidism - serum Ca2+

increased

28

primary hyperparathyroidism - Pi

decreased

29

primary hyperparathyroidism - ALP

increased

30

primary hyperparathyroidism - PTH

increased

31

secondary hyperparathyroidism - serum Ca2+

decreased

32

secondary hyperparathyroidism - Pi

increased

33

secondary hyperparathyroidism - ALP

increased

34

secondary hyperparathyroidism - PTH

increased

35

secondary hyperparathyroidism - is often due to

chronic renal disease

36

• What lab value is elevated in Paget disease of bone? What type of bony architecture is seen?

Alkaline phosphatase; one sees abnormal "mosaic" bone architecture

37

• Describe a distinguishing characteristic of the bones of patients with long-term osteitis fibrosa cystica.

They have brown tumors (due to fibrous replacement of bone) or subperiosteal thinning

38

• Overly soft bones are associated with the disease ____. Brown tumors are associated with the disease ____.

Osteomalacia/rickets; osteitis fibrosa cystica

39

• A patient has increased serum calcium and phosphate with decreased PTH. What condition can lead to this lab profile?

Hypervitaminosis D, due to oversupplementation or granulomatous diseases such as sarcoidosis

40

• What is the difference between primary and secondary hyperparathyroidism in terms of causative pathologies?

Primary is due to PTH secretion (e.g., from a tumor), and secondary is a response to renal failure with concomitant vitamin D deficiency

41

• What are some causes of primary hyperparathyroidism?

Parathyroid hyperplasia, a parathyroid adenoma, idiopathic

42

• What is the lab profile for calcium, phosphate, PTH, and ALP in a patient with primary hyperparathyroidism?

High calcium, low phosphate, high ALP, high PTH

43

• What is the lab profile for calcium, phosphate, PTH, and ALP in a patient with secondary hyperparathyroidism?

Low calcium, high phosphate, high ALP, high PTH

44

• What bone density disease has no laboratory abnormalities?

Osteoporosis, which has a decrease in bone mass

45

• In osteitis fibrosa cystica due to primary hyperparathyroidism, what happens to calcium, phosphate, ALP, and PTH levels?

Calcium, ALP, and PTH levels are increased, whereas phosphate is decreased

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