Flashcards in 24.Lab values in bone disorders Deck (45)
Osteoporosis - serum Ca2+
Osteoporosis - Pi
Osteoporosis - ALP
Osteopetrosis - PTH
Osteopetrosis - serum Ca2+
normal / decreased
Osteopetrosis - serum Ca2+ - when is decreaed
in severe malignant disease
Paget disease of bones ( osteitis deformans ) - serum Ca2+
Paget disease of bones ( osteitis deformans ) -Pi
Paget disease of bones ( osteitis deformans ) - ALP
Paget disease of bones ( osteitis deformans ) - PTH
osteomalacia / rickets - serum Ca2+
osteomalacia / rickets - Pi
osteomalacia / rickets -ALp
osteomalacia / rickets - PTH
caused of hypervitaminosis D
2. granulomatous disease
hypervitaminosis D - Pi
hypervitaminosis D - ALP
hypervitaminosis D -PTH
hypervitaminosis D - serum Ca2+
Primary Hyperpatathyroidism causes
osteitis fibrosa cystica
primary hyperparathyroidism is caused by
2. parathyroid hyperplasia
3. parathryoid adenoma
4. parathyroid carcinoma
osteitis fibrosa cystica is also called ( why )
because its is filled with brown
osteitis fibrosa cystica causes ( appearance )
primary hyperparathyroidism - serum Ca2+
primary hyperparathyroidism - Pi
primary hyperparathyroidism - ALP
primary hyperparathyroidism - PTH
secondary hyperparathyroidism - serum Ca2+
secondary hyperparathyroidism - Pi
secondary hyperparathyroidism - ALP
secondary hyperparathyroidism - PTH
secondary hyperparathyroidism - is often due to
chronic renal disease
• What lab value is elevated in Paget disease of bone? What type of bony architecture is seen?
Alkaline phosphatase; one sees abnormal "mosaic" bone architecture
• Describe a distinguishing characteristic of the bones of patients with long-term osteitis fibrosa cystica.
They have brown tumors (due to fibrous replacement of bone) or subperiosteal thinning
• Overly soft bones are associated with the disease ____. Brown tumors are associated with the disease ____.
Osteomalacia/rickets; osteitis fibrosa cystica
• A patient has increased serum calcium and phosphate with decreased PTH. What condition can lead to this lab profile?
Hypervitaminosis D, due to oversupplementation or granulomatous diseases such as sarcoidosis
• What is the difference between primary and secondary hyperparathyroidism in terms of causative pathologies?
Primary is due to PTH secretion (e.g., from a tumor), and secondary is a response to renal failure with concomitant vitamin D deficiency
• What are some causes of primary hyperparathyroidism?
Parathyroid hyperplasia, a parathyroid adenoma, idiopathic
• What is the lab profile for calcium, phosphate, PTH, and ALP in a patient with primary hyperparathyroidism?
High calcium, low phosphate, high ALP, high PTH
• What is the lab profile for calcium, phosphate, PTH, and ALP in a patient with secondary hyperparathyroidism?
Low calcium, high phosphate, high ALP, high PTH
• What bone density disease has no laboratory abnormalities?
Osteoporosis, which has a decrease in bone mass