2.5 Fatty Acid Oxidation & Ketogenesis Flashcards Preview

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Flashcards in 2.5 Fatty Acid Oxidation & Ketogenesis Deck (23):
0

Why is lipid an effective energy storage molecule

Yield of Acetyl CoA, NADH and FADH2 are much larger than what glucose can yield

1

Fatty Oxidation is favored by what type of insulin/glucagon ratio?

Favored by a low Insulin/Glucagon ratio

2

What hormones activate TAG degradation by lipase?

Glucagon and Epinephrine

3

What enzyme adds a CoA on to a FFA after the FA has diffused across the cell?

Fatty Acid-CoA Synthetase

4

What does CPT1 do?

It catalyzes the reaction of FA-CoA to Acyl-carnitine so that the FA can get through the mitochondrial membrane

5

How does Acyl-Carnitine diffuse across the mitochondrial membrane?

Through CAT, an antiporter that transports Carnitine back and Acyl-Carnitine in

6

What does CPT2 do?

It reconverts Acyl-Carnitine back to FA-CoA within the mitochondrial matrix

7

What inhibits CPT1?

Malonyl CoA. A substrate for Fat synthesis

8

Where is B oxidation found?

In the mitochondrial cells of the liver

9

How does insulin, glucagon and energy levels regulate B oxidation?

INCREASE IN ACTIVITY
Low insulin
High Glucagon
Low Energy levels

10

What are the four reactions found in B oxidation

Oxidation --> Hydration --> Oxidation --> Thiolysis

11

What is the first step in B oxidation and what is released during this reaction?

Oxidation --> FADH2

12

What is the third step of B oxidation and what is released?

Oxidation --> NADH

13

What is the last step of b oxidation?

Thiolysis --> Addition of CoA

14

One pass of Beta Oxidation yields?

1 Acetyl CoA, 1 NADH and 1FADH2

15

What is the role of peroxisomes in B oxidation

It degrades Very long chain fatty acids

16

How is B oxidation different in Peroxisomes than in B oxidation

No NADH or FADH2

17

What are the final products of B oxidation in the Peroxisome

Octanoyl CoA and Acetyl CoA

18

During odd-numbered B oxidation, what is the fragment remaining that needs to be degraded?

Propionyl-CoA, A 3 carbon fragment

19

What is the intermediate during odd numbered B oxidation of FA

Methylmalonyl CoA
Propionyl-CoA --> Methylmalony COA --> Succinyl CoA

20

What enzyme converts Propionyl-CoA to Methylmalonyl CoA in odd numbered B Oxidation

Propionyl CoA Carboxylase

21

What enzyme catalyzes reaction of Methylmalony CoA to Succinyl CoA

Methylmalonyl CoA Mutase

22

When does the FA miss the first reaction of B Oxidation and doesn't produce FADH2

Unsaturated FA