255b advanced breast cancer Flashcards Preview

heme/onc > 255b advanced breast cancer > Flashcards

Flashcards in 255b advanced breast cancer Deck (11):
1

what stage is breast cancer that has spread to chest wall or is inflammatory but hasn't spread to other parts of the body?

IIIB

2

can people with IIIB breast cancer have long term survival?

yes, with neoadjuvant chemo to shrink tumor before surgery (inop tumor --> oper tumor)

3

ER+ BC Rx

Endocrine - Tamoxifen

then chemotherapy when patient no longer responds

4

HER2+ BC Rx? target? toxicity?

Anti-HER2 - Trastuzumab (trasTWOzumab)

HER-2 is a tyrosine kinase receptor

damages the heart

5

triple negative BC Rx

chemotherapy

6

are most BC either ER+ or PR+

yes, ~75% --> better odds of endocrine treatment working

7

source of estrogen in BC?

premenopause - ovaries

postmenopause - adrenal gland w/ aromatase conversion

8

tamoxifen

- at Breast
+ at endometrium (carcinoma)
+ at Bone

(Raloxifene is - at breast and endometrium)

9

aromatase inhibitor side effects

decreases E in post-menopausal women so causes increased symptoms of menopause

hot flashes, arthralgias, loss of bone, vaginal dryness

10

should you rebiopsy in metastatic BC?

yes, tumor cells can change and become more or less susceptible to varying therapies

11

denosumab - target? clinical use? notes?

RANK-L (from OB to OC)

osteoporosis - inhibits OC maturation (mimics osteoprotegrin)

DEN-OS-umab DENies OSteoclasts