Flashcards in 255b advanced breast cancer Deck (11):
what stage is breast cancer that has spread to chest wall or is inflammatory but hasn't spread to other parts of the body?
can people with IIIB breast cancer have long term survival?
yes, with neoadjuvant chemo to shrink tumor before surgery (inop tumor --> oper tumor)
ER+ BC Rx
Endocrine - Tamoxifen
then chemotherapy when patient no longer responds
HER2+ BC Rx? target? toxicity?
Anti-HER2 - Trastuzumab (trasTWOzumab)
HER-2 is a tyrosine kinase receptor
damages the heart
triple negative BC Rx
are most BC either ER+ or PR+
yes, ~75% --> better odds of endocrine treatment working
source of estrogen in BC?
premenopause - ovaries
postmenopause - adrenal gland w/ aromatase conversion
- at Breast
+ at endometrium (carcinoma)
+ at Bone
(Raloxifene is - at breast and endometrium)
aromatase inhibitor side effects
decreases E in post-menopausal women so causes increased symptoms of menopause
hot flashes, arthralgias, loss of bone, vaginal dryness
should you rebiopsy in metastatic BC?
yes, tumor cells can change and become more or less susceptible to varying therapies